The Glucocorticoid Receptor in Cardiovascular Health and Disease

Autor: Tie-Ning Zhang, Julie E. Goodwin, Bing Liu, Jessica K Knight
Jazyk: angličtina
Rok vydání: 2019
Předmět:
0301 basic medicine
circadian rhythm
Hydrocortisone
medicine.medical_treatment
Gene regulatory network
heart failure
Endogeny
Inflammation
Disease
Review
nuclear hormone
030204 cardiovascular system & hematology
Bioinformatics
Cardiovascular System
sepsis
03 medical and health sciences
0302 clinical medicine
Glucocorticoid receptor
Receptors
Glucocorticoid
cardiovascular disease
glucocorticoid receptor
Medicine
Animals
Humans
lcsh:QH301-705.5
Polymorphism
Genetic
business.industry
blood pressure
General Medicine
Prognosis
3. Good health
Steroid hormone
030104 developmental biology
lcsh:Biology (General)
Nuclear receptor
Gene Expression Regulation
Cardiovascular Diseases
medicine.symptom
business
Glucocorticoid
hormones
hormone substitutes
and hormone antagonists
medicine.drug
Signal Transduction
Zdroj: Cells
Cells, Vol 8, Iss 10, p 1227 (2019)
ISSN: 2073-4409
Popis: The glucocorticoid receptor is a member of the nuclear receptor family that controls many distinct gene networks, governing various aspects of development, metabolism, inflammation, and the stress response, as well as other key biological processes in the cardiovascular system. Recently, research in both animal models and humans has begun to unravel the profound complexity of glucocorticoid signaling and convincingly demonstrates that the glucocorticoid receptor has direct effects on the heart and vessels in vivo and in vitro. This research has contributed directly to improving therapeutic strategies in human disease. The glucocorticoid receptor is activated either by the endogenous steroid hormone cortisol or by exogenous glucocorticoids and acts within the cardiovascular system via both genomic and non-genomic pathways. Polymorphisms of the glucocorticoid receptor are also reported to influence the progress and prognosis of cardiovascular disease. In this review, we provide an update on glucocorticoid signaling and highlight the critical role of this signaling in both physiological and pathological conditions of the cardiovascular system. With increasing in-depth understanding of glucocorticoid signaling, the future is promising for the development of targeted glucocorticoid treatments and improved clinical outcomes.
Databáze: OpenAIRE
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