Macrophage Markers Are Poorly Associated With Liver Histology in Children With Nonalcoholic Fatty Liver Disease
| Autor: | Rita De Vito, Anna Alisi, Søren Rittig, Henning Grønbæk, Konstantin Kazankov, Birgitte Mahler, Valerio Nobili, Holger Jon Møller |
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| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Adolescent Cross-sectional study Antigens Differentiation Myelomonocytic Receptors Cell Surface Gastroenterology Cohort Studies Pathogenesis 03 medical and health sciences 0302 clinical medicine Antigens CD Non-alcoholic Fatty Liver Disease Internal medicine Nonalcoholic fatty liver disease Humans Medicine Child Randomized Controlled Trials as Topic business.industry Macrophages Macrophage Activation medicine.disease Obesity digestive system diseases Cross-Sectional Studies 030104 developmental biology Liver Pediatrics Perinatology and Child Health Cohort Female 030211 gastroenterology & hepatology Steatosis business CD163 Biomarkers Cohort study |
| Zdroj: | Kazankov, K, Alisi, A, Møller, H J, De Vito, R, Rittig, S, Mahler, B, Nobili, V & Grønbæk, H 2018, ' Macrophage Markers are Poorly Associated with Liver Histology in Children with Non-Alcoholic Fatty Liver Disease ', Journal of Pediatric Gastroenterology and Nutrition, vol. 67, no. 5, pp. 635–642 . https://doi.org/10.1097/MPG.0000000000002111 |
| ISSN: | 1536-4801 0277-2116 |
| Popis: | OBJECTIVES: We have previously demonstrated associations between the macrophage activation marker soluble (s)CD163 and histology of non-alcoholic fatty liver disease (NAFLD) in adults, and elevated sCD163 levels in obese children with NAFLD. However, macrophage activation has not been investigated in children with biopsy-proven NAFLD, which was the objective of the present study.METHODS: We used in-house ELISAs to measure sCD163 and the novel macrophage marker soluble mannose receptor (sMR) in a cross-sectional (n = 155) pediatric NAFLD cohort, and a cohort of NAFLD children (n = 36) undergoing a randomized trial by the probiotic VSL#3. We included 56 healthy non-obese children for comparison.RESULTS: Levels of sCD163 and sMR were higher in both of the NAFLD cohorts compared with controls (p CONCLUSION: The macrophage activation markers sCD163 and sMR showed poor associations with liver histology in two different cohorts of children with biopsy-proven NAFLD, and none of the markers decreased during successful intervention. These results are in contrast with studies of adult NAFLD and may suggest a possibility of different roles for macrophages in the pathogenesis of adult and pediatric NAFLD. |
| Databáze: | OpenAIRE |
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