Recent advances in mesenchymal stem cell membrane-coated nanoparticles for enhanced drug delivery
| Autor: | Yuanfeng Xin, Zhongmin Liu, Yifei Hua, Chao Zhang, Wenjie Tang, Mian Wang, Hao Cao, Wanlu Li, Thomas J. Webster |
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| Rok vydání: | 2021 |
| Předmět: |
0303 health sciences
Chemistry Cell Mesenchymal stem cell Biomedical Engineering Mesenchymal Stem Cells 02 engineering and technology 021001 nanoscience & nanotechnology Cell biology Cell membrane 03 medical and health sciences Drug Delivery Systems Nanomedicine medicine.anatomical_structure Membrane Pharmaceutical Preparations Targeted drug delivery Drug delivery medicine Nanoparticles General Materials Science 0210 nano-technology 030304 developmental biology Homing (hematopoietic) |
| Zdroj: | Biomaterials Science. 9:1088-1103 |
| ISSN: | 2047-4849 2047-4830 |
| DOI: | 10.1039/d0bm01164a |
| Popis: | Studies of nanomedicine have achieved dramatic progress in recent decades. However, the main challenges that traditional nanomedicine has to overcome include low accumulation at target sites and rapid clearance from the blood circulation. An interesting approach using cell membrane coating technology has emerged as a possible way to overcome these limitations, owing to the enhanced targeted delivery and reduced immunogenicity of cell membrane moieties. Mesenchymal stem cell (MSC) therapy has been investigated for treating various diseases, ranging from inflammatory diseases to tissue damage. Recent studies with engineered modified MSCs or MSC membranes have focused on enhancing cell therapeutic efficacy. Therefore, bioengineering strategies that couple synthetic nanoparticles with MSC membranes have recently received much attention due to their homing ability and tumor tropism. Given the various membrane receptors on their surfaces, MSC membrane-coated nanoparticles are an effective method with selective targeting properties, allowing entry into specific cells. Here, we review recent progress on the use of MSC membrane-coated nanoparticles for biomedical applications, particularly in the two main antitumor and anti-inflammatory fields. The combination of a bioengineered cell membrane and synthesized nanoparticles presents a wide range of possibilities for the further development of targeted drug delivery, showing the potential to enhance the therapeutic efficacy for treating various diseases. |
| Databáze: | OpenAIRE |
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