Clinical outcomes of Preimplantation genetic testing (PGT) application in couples with chromosomal inversion, a study in the Chinese Han population

Autor: Wenjie Jiang, Juanjuan Lu, Yueting Zhu, Hongchang Li, Junhao Yan, Yuhan Shao, Jing Li
Rok vydání: 2020
Předmět:
0301 basic medicine
Male
Pregnancy Rate
law.invention
Miscarriage
0302 clinical medicine
Endocrinology
Randomized controlled trial
law
Pregnancy
lcsh:Reproduction
Chromosomal inversion
Comparative Genomic Hybridization
Family Characteristics
030219 obstetrics & reproductive medicine
medicine.diagnostic_test
Obstetrics
Aneuploid
Obstetrics and Gynecology
Middle Aged
Treatment Outcome
Female
Live birth
Live Birth
Adult
medicine.medical_specialty
China
lcsh:QH471-489
Reproductive medicine
Fertilization in Vitro
lcsh:Gynecology and obstetrics
Pregnancy outcome
03 medical and health sciences
Young Adult
medicine
Preimplantation genetics testing (PGT)
Humans
Genetic Testing
Sperm Injections
Intracytoplasmic
Adverse effect
lcsh:RG1-991
Preimplantation Diagnosis
Genetic testing
Retrospective Studies
business.industry
Research
Infant
Newborn
Retrospective cohort study
medicine.disease
030104 developmental biology
Reproductive Medicine
Chromosome Inversion
business
Developmental Biology
Zdroj: Reproductive Biology and Endocrinology : RB&E
Reproductive Biology and Endocrinology, Vol 18, Iss 1, Pp 1-9 (2020)
ISSN: 1477-7827
Popis: Background Chromosomal inversion was considered to have adverse effects on pregnancy outcomes through abnormal gametogenesis. The purpose of this retrospective study was to investigate whether preimplantation genetic testing (PGT) improves pregnancy outcomes for couples with chromosomal inversion. Methods A total of 188 cycles from 165 couples with one chromosomal inversion carrier were divided into two groups: PGT (136 cycles, 125 couples) and non-PGT (52 cycles, 50 couples). Biochemical pregnancy, clinical pregnancy, ongoing pregnancy, miscarriage and live birth rates of their first transfer cycles, as well as cumulative live birth rates of each cycle and euploidy rates, were analyzed. Results There were no statistically significant differences in the pregnancy outcomes between the two groups. The euploidy rate of pericentric inversion carriers was not higher than that of paracentric inversion carriers in PGT group (60.71% vs 50.54%, P = 0.073). Similarly, the euploid rate of male carriers was not higher than that of female carriers (61.2% vs 56.1%, P = 0.256). Conclusions Due to limitation of retrospective study and small sample size, our current data showed that PGT cannot provide prominent benefits for inversion carriers in the Chinese Han population. Further prospective randomized controlled trials are needed to evaluate the effects of PGT.
Databáze: OpenAIRE
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