Induction of type C RNA virus from cultured rabbit lymphosarcoma cells
| Autor: | H Meier, H G Bedigian, R. R. Fox |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
DNA polymerase
viruses Immunology Virus Replication Microbiology Virus Cell Line Epitopes chemistry.chemical_compound Idoxuridine Virology Complementary DNA Animals RNA Viruses biology Lymphoma Non-Hodgkin RNA-Directed DNA Polymerase RNA virus biology.organism_classification Molecular biology Retroviridae chemistry Viral replication Cell culture Insect Science biology.protein Rabbits DNA Research Article |
| Zdroj: | Journal of Virology. 27:313-319 |
| ISSN: | 1098-5514 0022-538X |
| DOI: | 10.1128/jvi.27.2.313-319.1978 |
| Popis: | Type C RNA virus(es) was readily released from primary lymphosarcoma cell cultures of WH/J rabbits after induction with halogenated pyrimidines. The virus contained an RNA-directed DNA polymerase and the p30 structural protein. The rabbit virus RNA-directed DNA polymerase and p30 protein shared antigenic homologies with other mammalian type C oncornaviruses but appear to also possess unique antigenic determinants. Normal rabbit liver contained DNA homologous to a 3H-labeled complementary DNA transcript of the rabbit viral genome, indicating that type C viral genetic information is present in at least the WH/J strain of rabbits. |
| Databáze: | OpenAIRE |
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