Macrophage migration inhibitory factor-deficient mice are resistant to ovariectomy-induced bone loss

Autor:	Norio Amizuka, Shigeki Oshima, Jun Nishihira, Kazunori Yasuda, Akio Minami, Kazuharu Irie, Yoshikazu Koyama, Satoshi Watanabe, Minqi Li, Shin Onodera
Jazyk:	angličtina
Rok vydání:	2006
Předmět:	medicine.medical_specialty Deficient mice medicine.drug_class medicine.medical_treatment animal diseases Ovariectomy Osteoporosis Biophysics Osteoclasts chemical and pharmacologic phenomena Cell Count Biology Biochemistry Bone and Bones Pathogenesis Mice Structural Biology Osteoclast Internal medicine Genetics medicine otorhinolaryngologic diseases Animals Humans Molecular Biology Macrophage Migration-Inhibitory Factors Cytokine Osteoporosis Postmenopausal 491.8 Mice Knockout Macrophage migration inhibitory factor Interleukin Cell Biology respiratory system medicine.disease biological factors Disease Models Animal medicine.anatomical_structure Endocrinology Estrogen Tumor necrosis factor alpha Female Disease Susceptibility Interleukin-1
Zdroj:	FEBS Letters. 580(5):1251-1256
ISSN:	0014-5793
Popis:	A link between macrophage migration inhibitory factor (MIF) and estrogen has recently emerged. We examined the involvement of MIF in osteoporotic changes in bone after ovariectomy (OVX), and revealed that MIF-deficient mice (MIF-KO) were completely protected from this phenomenon. The increase in osteoclast number per bone surface and serum IL-1β levels, which were observed in wild-type mice after OVX, did not occur in MIF KO. Our data suggest that MIF plays an important role in the pathogenesis of postmenopausal osteoporosis, and could be a novel target for the treatment of this disease.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51db2cda16e8ea8f40e7f1f5f01d5f4a http://hdl.handle.net/2115/5848 Zobrazit plný text záznamu Plný text