An Immunohistochemical Study of p53 Protein Expression in Classical Kaposi's Sarcoma
| Autor: | Sigalit Kilim, Rachel Friedman-Birnbaum, Chaim Lichtig, Reuven Bergman, Michal Ramon |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Skin Neoplasms medicine.drug_class Dermatology Biology Monoclonal antibody Pathology and Forensic Medicine Lesion Gene expression medicine Humans Sarcoma Kaposi Kaposi's sarcoma Aged Neoplasm Staging Aged 80 and over General Medicine Middle Aged medicine.disease Immunohistochemistry Tumor progression P53 protein Female Sarcoma Tumor Suppressor Protein p53 medicine.symptom |
| Zdroj: | The American Journal of Dermatopathology. 18:367-370 |
| ISSN: | 0193-1091 |
| DOI: | 10.1097/00000372-199608000-00007 |
| Popis: | The present study was performed to determine the frequency of p53 protein immunoreactivity in classical Kaposi's sarcoma (KS) as a whole and in relation to the histological subtypes which are considered to correspond to the developmental stages of the tumor. The accumulation of p53 protein was studied immunohistochemically using monoclonal antibody BP53-12 on formalin-fixed paraffin-embedded sections of 36 KS lesions, of which 14 were classified histologically as early type and 22 as spindle-cell or mixed type. No positive immunoreactivity was detected in any of the 14 early-type lesions. Among the 22 spindle-cell and mixed variants, positive staining was detected in 5-10% of the tumor cells in one lesion, 1-5% of the cells in six lesions, and in |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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