HIV type 1 Gag as a target for antiviral therapy
| Autor: | Eric O. Freed, Abdul A. Waheed |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Virus particle assembly
Anti-HIV Agents viruses Immunology Human immunodeficiency virus (HIV) HIV Infections Biology HIV Envelope Protein gp120 medicine.disease_cause Virus Replication gag Gene Products Human Immunodeficiency Virus ANTIRETROVIRAL AGENTS Virology Drug Discovery medicine Humans Transcription factor Review Articles Drug discovery Antiviral therapy Infectious Diseases Viral replication HIV-1 Function (biology) Transcription Factors |
| Zdroj: | AIDS research and human retroviruses. 28(1) |
| ISSN: | 1931-8405 |
| Popis: | The Gag proteins of HIV-1 are central players in virus particle assembly, release, and maturation, and also function in the establishment of a productive infection. Despite their importance throughout the replication cycle, there are currently no approved antiretroviral therapies that target the Gag precursor protein or any of the mature Gag proteins. Recent progress in understanding the structural and cell biology of HIV-1 Gag function has revealed a number of potential Gag-related targets for possible therapeutic intervention. In this review, we summarize our current understanding of HIV-1 Gag and suggest some approaches for the development of novel antiretroviral agents that target Gag. |
| Databáze: | OpenAIRE |
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