Multimodality treatment of undifferentiated pleomorphic soft tissue sarcoma of the extremity (eUPS) in the elderly
| Autor: | Roos F. Bleckman, Ibtissam Acem, Veroniek M. van Praag, Desirée M.J. Dorleijn, Cornelis Verhoef, Yvonne M. Schrage, Rick M.L. Haas, Michiel A.J. van de Sande, null the collaborative Persarc research group, Han Bonenkamp, Robert J. van Ginkel, Dirk J. Grünhagen, Lee M. Jeys, Johnny Keller, Emelie Styring, Joanna Szkandera, Olga Zaikova |
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| Přispěvatelé: | Surgery, Guided Treatment in Optimal Selected Cancer Patients (GUTS) |
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Radiotherapy
Extremities Sarcoma Soft Tissue Neoplasms General Medicine Age group Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14] All institutes and research themes of the Radboud University Medical Center Oncology SDG 3 - Good Health and Well-being Surgical oncology Humans Surgery Neoplasm Recurrence Local Aged Retrospective Studies |
| Zdroj: | European Journal of Surgical Oncology, 48(5), 985-993. W.B. Saunders European Journal of Surgical Oncology, 48, 985-993 European Journal of Surgical Oncology, 48, 5, pp. 985-993 European Journal of Surgical Oncology, 48(5), 985-993. ELSEVIER SCI LTD Bleckman, R F, Acem, I, van Praag, V M, Dorleijn, D M J, Verhoef, C, Schrage, Y M, Haas, R M L, van de Sande, M A J & the collaborative PERSARC research group 2022, ' Multimodality treatment of undifferentiated pleomorphic soft tissue sarcoma of the extremity (eUPS) in the elderly ', European Journal of Surgical Oncology, vol. 48, no. 5, pp. 985-993 . https://doi.org/10.1016/j.ejso.2021.12.008 European Journal of Surgical Oncology, 48, 985-993. ELSEVIER SCI LTD |
| ISSN: | 0748-7983 |
| DOI: | 10.1016/j.ejso.2021.12.008 |
| Popis: | Introduction: This subgroup analysis of undifferentiated pleomorphic soft tissue sarcoma of the extremity (eUPS) from the PERSARC collaborative group aimed to achieve a more personalized multimodality treatment approach for primary eUPS in elderly patients.Material and methods: A multicenter retrospective study including primary high-grade eUPS surgically treated with curative intent between 2000 and 2016. Overall survival (OS), local recurrence (LR) and distant metastasis (DM) curves were calculated by Kaplan Meier analysis. Cox proportional hazard models were used to determine the effect of radiotherapy.Results: From a total of 2511 patients with extremity soft tissue sarcoma (eSTS) of the PERSARC study collaborative; 703 patients with eUPS were included in this study. In elderly patients with eUPS 5-year OS, LR and DM were 35.4 (95%CI 29.3-42.8), 17.7 (95%CI 12.7-22.6) and 24.6 (95%CI 19.1-30.1). eUPS was significantly less treated with radiotherapy compared with other eSTS, especially in elderly patients. Patients with R1-R2 margins treated with radiotherapy had about half the risk of developing LR compared with patients treated without radiotherapy (HR = 0.454, p = 0.033).Conclusion: Elderly patients with eUPS were less often treated with radiotherapy and showed higher LR. Nowadays, given an increasing life expectancy in elderly patients, multimodality treatment should be considered. (C) 2021 The Authors. Published by Elsevier Ltd. |
| Databáze: | OpenAIRE |
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