Fish meal supplementation and ambulatory blood pressure in patients with hypertension: relevance of baseline membrane fatty acid composition
| Autor: | Leonardo A. Sechi, Lucio Mos, Francesca Pezzutto, Valeria Dialti, Cristiana Catena, GianLuca Colussi |
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| Rok vydání: | 2014 |
| Předmět: |
Counseling
Male Time Factors Trout Blood Pressure red blood cell membrane Longitudinal Studies Prospective Studies chemistry.chemical_classification food and beverages Blood Pressure Monitoring Ambulatory Middle Aged Fish oil Pulse pressure Circadian Rhythm Treatment Outcome Italy Saturated fatty acid Hypertension Fatty Acids Unsaturated lipids (amino acids peptides and proteins) Female Polyunsaturated fatty acid polyunsaturated fatty acids medicine.medical_specialty Ambulatory blood pressure nutritional counseling Chromatography Gas Systole Fish meal Internal medicine Internal Medicine medicine ambulatory blood pressure monitoring blood pressure hypertension saturated fatty acids Animals Humans Aged business.industry Erythrocyte Membrane Fatty acid eye diseases Blood pressure Endocrinology Cross-Sectional Studies Logistic Models chemistry Seafood sense organs business |
| Zdroj: | American journal of hypertension. 27(3) |
| ISSN: | 1941-7225 |
| Popis: | Background Studies on fish oil effects on ambulatory blood pressure (ABP) are inconclusive. We evaluated fish effects on fatty acid composition of red blood cell (RBC) membrane and ABP values and tested the hypothesis that the starting membrane fatty acid composition affects the ability to incorporate additional polyunsaturated fatty acids (PUFA) and decrease blood pressure. Methods In 55 hypertensive patients, we measured RBC membrane fatty acid by gas chromatography and performed ABP monitoring. Patients received nutritional counseling and 3 weekly meals of trout rich in PUFA. In 42 patients, RBC membrane fatty acid and ABP were reassessed after 6 months. Results At baseline, the PUFA/saturated fatty acid (SFA) ratio of RBC membrane (PUFA/SFA) was inversely related to 24-hour, daytime, and nighttime systolic and pulse pressure, a relationship that was independent of covariables. At follow-up, the PUFA/SFA ratio increased in 20 (48%) of 42 patients. Patients with increased PUFA/SFA ratio at follow-up had lower baseline PUFA/SFA ratio than patients without such increase. Fish meal supplementation decreased 24-hour systolic and diastolic pressure only in patients who had increased PUFA/SFA ratio, a change that was more prominent during the nighttime. The change in PUFA/SFA was inversely and independently related to the change in 24-hour systolic and pulse pressure, and a logistic regression analysis indicated low baseline PUFA/SFA ratio as the only independent predictor of PUFA/SFA increase and blood pressure decrease. Conclusions The ability of fish meals to increase membrane PUFA content and decrease blood pressure in hypertensive patients depends upon the starting membrane fatty acid composition. |
| Databáze: | OpenAIRE |
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