Modulation of memory processing by glutamic acid receptor agonists and antagonists
| Autor: | James F. Flood, Joel L. Davis, Margaret L. Baker |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Agonist
Male Kainic acid medicine.drug_class Pharmacology Receptors N-Methyl-D-Aspartate chemistry.chemical_compound Mice Memory medicine Avoidance Learning Animals Quisqualic acid Receptor Molecular Biology Injections Intraventricular Dose-Response Relationship Drug General Neuroscience Glutamate receptor Long-term potentiation Glutamic acid Receptors Neurotransmitter chemistry Receptors Glutamate NMDA receptor Neurology (clinical) Developmental Biology |
| Zdroj: | Brain research. 521(1-2) |
| ISSN: | 0006-8993 |
| Popis: | Recent hypotheses suggesting a critical role of glutamate receptors in hippocampal long-term potentiation and memory processing suggested a closer examination of this transmitter's effect on memory processing in an in vivo setting. New Pharmacological antagonists allow for a separation and examination of various glutamate receptors and their role in memory processing. Mice were trained on a shock avoidance learning paradigm and injected intracerebroventricularly after training with agonists and antagonists of various classes of glutamate receptors. Retention was tested 1 week after training.N-Methyl- d -aspartate (NMDA) receptor agonists enhanced retention in a dose-dependent manner. The enhancement of retention by the non-NMDA agonist kainic acid and quisqualic acid was dose-dependent. l -Glutamic acid, but not d -glutamic acid, enhanced retention. Both NMDA and non-NMDA receptor antagonists produced dose-dependent impairment of retention for footshock training. Administration of the antagonists 24 h after did not impair memorry retention. |
| Databáze: | OpenAIRE |
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