Case report: narcolepsy type 2 due to temporal lobe glioma
| Autor: | Fengzhen Huang, Xiaojie Li, Yuangao Liao, Yan He, You Yang |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Multiple Sleep Latency Test
Adult Male hippocampus Excessive daytime sleepiness Hippocampus Neurological examination Temporal lobe 03 medical and health sciences 0302 clinical medicine medicine Humans 030212 general & internal medicine Clinical Case Report Narcolepsy medicine.diagnostic_test business.industry Brain Neoplasms Epworth Sleepiness Scale excessive daytime sleepiness General Medicine Glioma medicine.disease Temporal Lobe Orexin 030220 oncology & carcinogenesis Anesthesia medicine.symptom business narcolepsy type 2 Research Article |
| Zdroj: | Medicine |
| ISSN: | 1536-5964 |
| Popis: | Rationale: The orexin projection system includes the lateral hypothalamus, reticular activating structure, and ventrolateral preoptic nucleus, and this system is related to the pathogenesis of narcolepsy. Here, we report a case of narcolepsy type 2 caused by hippocampal glioma of the right temporal lobe. Patient concerns: A 44-year-old male farmer complained of excessive daytime sleepiness (EDS) over the past 3 months and more. Interventions: The lesion of the right anteromedial temporal lobe was removed and its pathological examination was carried out. Outcomes: General examination showed no abnormalities of his heart, lungs, or abdomen. Neurological examination showed no positive sign. The blood routine and biochemical examination were normal. He scored 7 on the Pittsburg sleep quality index, 16 on the Epworth sleepiness scale, 52 on the self-rating anxiety scale, and 48 on the self-rating depression scale. The multiple sleep latency test data showed 2 periods of sleep-onset rapid eyes movement period across 4 successive tests; the average sleep latency was under 8 minutes, and the rapid eyes movement latency was under 7 minutes. Lesion of glioma in hippocampus area of the right anteromedial temporal lobe was confirmed through magnetic resonance imaging, magnetic resonance spectroscopy, and histological examination. After surgical removal of the glioma from the hippocampus area of the right anteromedial temporal lobe, the patient's EDS symptoms disappeared immediately. He scored 3 on the Epworth sleepiness scale. During our follow-up three months later, he remained well with no complications. Diagnosis: We diagnosed the patient with narcolepsy type 2 according to the 3rd Edition of International Classification of Sleep Disorders (ICSD-3). Conclusion: The patient suffered from EDS and was diagnosed with narcolepsy type 2. The narcolepsy type 2 was linked to glioma of the hippocampus area. The hippocampus might be another part of regulating the sleep-arousal pathway, and the glioma secretion might interact with the orexin projection system. |
| Databáze: | OpenAIRE |
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