Efficacy of eprinomectin pour-on against gastrointestinal nematodes and the nasal bot fly (Oestrus ovis ) in sheep
| Autor: | Michel Alvinerie, P Lemercier, Hervé Hoste, Anne Lespine, Ph Dorchies, Philippe Jacquiet |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Insecticides
Veterinary medicine Nematoda 040301 veterinary sciences Sheep Diseases Eprinomectin Administration Cutaneous Oestrus ovis 030308 mycology & parasitology 0403 veterinary science Feces 03 medical and health sciences Animal science Pharmacokinetics Nose Diseases parasitic diseases Animals Intestinal Diseases Parasitic Nematode Infections Parasite Egg Count Ovis Anthelmintics 0303 health sciences Ivermectin Sheep General Veterinary biology Diptera Area under the curve Baths 04 agricultural and veterinary sciences General Medicine biology.organism_classification Teladorsagia circumcincta 3. Good health Treatment Outcome Area Under Curve Female Dose rate Haemonchus contortus |
| Zdroj: | Veterinary Record. 154:782-785 |
| ISSN: | 0042-4900 |
| DOI: | 10.1136/vr.154.25.782 |
| Popis: | The efficacy of the pour-on formulation of eprinomectin, at a dose rate of 0.5 mg/kg bodyweight, was assessed in sheep against three main species of gastrointestinal nematodes and against the nasal bot fly, Oestrus ovis, and some pharmacokinetic parameters were determined for 21 days after the treatment. By comparison with untreated control sheep, infected experimentally with Haemonchus contortus, Teladorsagia circumcincta and Trichostrongylus colubriformis, eprinomectin was 100 per cent effective against the two abomasal species and 99.5 per cent effective against T. colubriformis. In ewes naturally infected with the nasal bot fly, the efficacy of the drug against O. ovis was 97.7 per cent. The mean (se) systemic area under the curve (AUC) was 56.0 (26.2) ng/day/ml and the mean residence time was 5.3 (1.0) days, but there were wide variations between individual sheep. |
| Databáze: | OpenAIRE |
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