Lymphadenopathy in IgG4-related disease: a phenotype of severe activity and poor prognosis, with eotaxin-3 as a new biomarker
| Autor: | Kunio Sugahara, Jun Kikuchi, Satoshi Takanashi, Yuko Kaneko, Noriyasu Seki, Keiko Yoshimoto, Kenji Chiba, Tsutomu Takeuchi, Takanori Sasaki, Mitsuhiro Akiyama, Hidekata Yasuoka |
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| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine Eotaxin medicine.medical_specialty Lymphadenopathy Disease Gastroenterology 03 medical and health sciences 0302 clinical medicine Rheumatology Recurrence Internal medicine Eosinophilia parasitic diseases medicine Humans Pharmacology (medical) Correlation of Data 030203 arthritis & rheumatology integumentary system Chemokine CCL26 business.industry Gene Expression Profiling fungi Patient Acuity Middle Aged medicine.disease Phenotype Up-Regulation 030104 developmental biology Cohort Biomarker (medicine) Female IgG4-related disease Immunoglobulin G4-Related Disease medicine.symptom business Biomarkers Glucocorticoid medicine.drug |
| Zdroj: | Rheumatology. 60:967-975 |
| ISSN: | 1462-0332 1462-0324 |
| DOI: | 10.1093/rheumatology/keaa648 |
| Popis: | Objective To clarify relevant proteins and clinical characteristics of a phenotype of IgG4-related disease (IgG4-RD) with lymphadenopathy. Methods We enrolled patients newly diagnosed with IgG4-RD in our department between January 2000 and June 2018 and performed proteomic analysis to measure serum concentrations of 1305 proteins. We extracted proteins overexpressed in patients with IgG4-RD with lymphadenopathy by comparing between those with lymphadenopathy, those without lymphadenopathy and healthy controls. We further reviewed all the patients with IgG4-RD in our institution and investigated the characteristics and prognosis of the patients with IgG4-RD with lymphadenopathy. Results Eighty-five patients with IgG4-RD were enrolled, of which, 55% had lymphadenopathy. Proteomic analysis in 31 patients with IgG4-RD and 6 healthy controls revealed that eotaxin-3 was a potential serum biomarker in the patients with lymphadenopathy versus those without lymphadenopathy and healthy controls. A cohort of 85 patients with IgG4-RD demonstrated that patients with lymphadenopathy showed a significantly higher serum IgG4, IgG4:IgG ratio, IgG4-RD responder index and eosinophilia (P Conclusion Lymphadenopathy in IgG4-RD represents a phenotype associated with high disease activities, eosinophilia and relapsing disease. Eotaxin-3 is a novel biomarker related to IgG4-RD with lymphadenopathy. |
| Databáze: | OpenAIRE |
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