Presymptomatic differences in Toll-like receptor function in infants who have allergy
| Autor: | L.A. Breckler, May Ali, Anita H. J. van den Biggelaar, Elysia M. Hollams, Bonita W.Y. Chow, Paul S. Noakes, Meri K. Tulic, Catherine A. Thornton, Susan L. Prescott |
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| Rok vydání: | 2008 |
| Předmět: |
Male
Allergy Immunology Mothers Atopy Hygiene hypothesis Food allergy Pregnancy Immunopathology medicine Hypersensitivity Immunology and Allergy Animals Humans RNA Messenger Sensitization Toll-like receptor business.industry Toll-Like Receptors Infant Newborn Infant Atopic dermatitis medicine.disease Toll-Like Receptor 3 Pregnancy Complications Toll-Like Receptor 4 medicine.anatomical_structure Logistic Models Maternal Exposure Animals Domestic Leukocytes Mononuclear Cytokines Female business |
| Zdroj: | The Journal of allergy and clinical immunology. 122(2) |
| ISSN: | 1097-6825 |
| Popis: | Background: Microbial exposure might play a key role in allergy development, but little is known about the role of Tolllike receptors (TLRs). Objective: This study explored the association between neonatal TLR microbial recognition/function, allergy risk (maternal allergy), and prospective allergy development. Methods: Cord blood mononuclear cells (n 5 111) were cultured either alone or with optimal concentrations of TLR ligands: lipoteichoic acid (TLR2), polyinosinicpolycytidylic acid (TLR3), LPS with IFN-g (TLR4), flagellin (TLR5), imiquimod R837 (TLR7), or CpG (TLR9). Cytokine responses were assessed in relation to allergy risk (maternal allergy) and allergy outcomes (sensitization, food allergy, and atopic dermatitis) at 12 months of age. Results: Maternal allergy (n 5 59) was associated with significantly higher neonatal IL-12 and IFN-g responses to TLR2, TLR3, and TLR4 activation, whereas TNF-a and IL-6 responses to TLR2, TLR4, and TLR5 activation were significantly higher in newborns who subsequently had allergic disease (n 5 32). Notably, consistent with previous reports, newborns who had disease had lower TH1 IFN-g response to mitogens (PHA). Conclusion: Allergic disease was associated with increased (rather than decreased) perinatal TLR responses. Further studies are needed to determine how these responses track in the postnatal period and whether this relative hyperresponsiveness is a product of intrauterine influences, including maternal atopy, functional genetic polymorphisms, or both. (J Allergy Clin Immunol 2008;122:391-9.) |
| Databáze: | OpenAIRE |
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