SYM 2206 (a potent non-competitive AMPA receptor antagonist) elevates the threshold for maximal electroshock-induced seizures in mice
| Autor: | Magdalena Florek-Luszczki, Maria W. Kondrat-Wróbel, Jarogniew J. Luszczki, Magdalena Leszkowicz |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
tid50 medicine.medical_treatment Hindlimb AMPA receptor Stimulus (physiology) sym 2206 Biochemistry Tonic (physiology) threshold for maximal electroshock-induced seizures Internal medicine medicine mice Molecular Biology Pharmacology Chemistry tid20 Antagonist General Medicine Maximal electroshock Anticonvulsant Endocrinology Anesthesia Medicine Non competitive |
| Zdroj: | Current Issues in Pharmacy and Medical Sciences, Vol 27, Iss 2, Pp 80-83 (2014) |
| ISSN: | 2300-6676 |
| Popis: | The aim of this study was to determine the effect of SYM 2206 (a potent non-competitive AMPA receptor antagonist) on the threshold for maximal electroshock (MEST)-induced seizures in mice. Electroconvulsions were produced in mice by means of a current (sinewave, 50 Hz, maximum 500 V, strength from 4 to 14 mA, 0.2-s stimulus duration, tonic hind limb extension taken as the endpoint) delivered via ear-clip electrodes. SYM 2206 administered systemically (i.p.), 30 min before the MEST test, at doses of 2.5 and 5 mg/kg, did not alter the threshold for maximal electroconvulsions in mice. In contrast, SYM 2206 at doses of 10 and 20 mg/kg significantly elevated the threshold for maximal electroconvulsions in mice (P20 and TID50 values) that elevate the threshold in drug-treated animals over the threshold in control animals. The experimentally derived TID20 and TID50 values for SYM 2206 were 4.25 and 10.56 mg/kg, respectively. SYM 2206 dose-dependently increased the threshold for MEST-induced seizures, suggesting the anticonvulsant action of the compound in this seizure model in mice. |
| Databáze: | OpenAIRE |
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