Tumid Lupus Erythematosus and Systemic Lupus Erythematosus: A Report on Their Rare Coexistence
| Autor: | Shraddha Jatwani, Karan Jatwani, Oluwasegun S Osholowu, Karan Chugh |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Tumid Lupus Erythematosus
medicine.medical_specialty Anti-nuclear antibody Dermatology rash 030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine Rheumatology systemic lupus erythematosus immune system diseases Internal Medicine Ultraviolet light medicine tumid lupus skin and connective tissue diseases Systemic lupus erythematosus medicine.diagnostic_test business.industry General Engineering Hydroxychloroquine medicine.disease Rash Skin biopsy Histopathology medicine.symptom business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Cureus |
| ISSN: | 2168-8184 |
| DOI: | 10.7759/cureus.7545 |
| Popis: | Tumid lupus erythematosus (TLE) is a rare variant of cutaneous lupus erythematosus. Clinically, it lacks typical changes found in discoid lupus and antinuclear antibodies (ANA) levels are elevated in only 10% of the patients. Coexistent systemic lupus erythematosus (SLE) has been reported to be rare, and literature shows only a few case reports. We present a case of coexistent tumid lupus and SLE. We present a case of a 48-year-old Caucasian female who presented with chronic facial rash, photosensitivity, intermittent oral ulcers, joint pain with morning stiffness, and unintentional weight loss. Laboratory studies showed positive ANA at 1:640, elevated erythrocyte sedimentation rate, positive anticardiolipin immunoglobulin (Ig) G, anticardiolipin IgM, and anti-beta-2 glycoprotein IgM. Skin biopsy of the rash showed a superficial and deep dense lymphocytic infiltrate with mucin deposition, histopathology favoring tumid lupus. The patient was diagnosed with TLE with SLE and was started on hydroxychloroquine with improvement in her rash. Ultraviolet light and certain medications have been proven to play a role in the pathogenesis of tumid lupus. It usually responds to photoprotection, topical treatment, or oral antimalarial therapy. |
| Databáze: | OpenAIRE |
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