Liver Pathology in First Presentation Diabetic Ketoacidosis at Autopsy
| Autor: | Anita Lal, Christopher M. Milroy, Jacqueline L. Parai |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Pediatrics
medicine.medical_specialty Forensic pathology Alcoholic liver disease endocrine system diseases Diabetic ketoacidosis business.industry nutritional and metabolic diseases medicine.disease Sudden death Pathology and Forensic Medicine Ketoacidosis Impaired glucose tolerance 03 medical and health sciences 0302 clinical medicine Diabetes mellitus Nonalcoholic fatty liver disease medicine Original Article 030211 gastroenterology & hepatology 030216 legal & forensic medicine business |
| Zdroj: | Academic Forensic Pathology. 6:271-280 |
| ISSN: | 1925-3621 |
| DOI: | 10.23907/2016.028 |
| Popis: | Diabetes mellitus is an enormous health burden on developed and developing nations. Eight percent of people in the United States are stated to have diabetes mellitus and 79 million people have impaired glucose tolerance. Sudden death from diabetic ketoacidosis (DKA) is common and nonalcoholic fatty liver disease (NAFLD) is a frequent finding in patients with diabetes mellitus and impaired glucose tolerance. Diabetic ketoacidosis accounts for around 1% of autopsy cases in our units and 25% of these cases did not have a previous diagnosis of diabetes mellitus. We have analyzed for the presence of NAFLD in 16 patients dying on first presentation of DKA. Some degree of NAFLD was present in all cases, with all but one case having some degree of steatosis and some degree of fibrosis was present in 14 out of 16 cases, though none where cirrhotic. Inflammation was present in nine of 13 cases and glyogenated nuclei in five of 13 cases. NAFLD can be well established in patients dying of DKA who were not known to be diabetic before death. The pathology shares features with alcoholic liver disease. They should not be mistakenly diagnosed as dying of other causes of ketoacidosis based upon the liver pathology present. |
| Databáze: | OpenAIRE |
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