Distribution of 15- and 137-mu diameter microspheres in the dog lung in the axial plane
| Autor: | Laurence W. Hedlund, C C Harris, Caroline Chiles, Daniel C. Sullivan, R. Kubek, J. Tsai, Charles E. Putman |
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| Rok vydání: | 1986 |
| Předmět: |
Pulmonary Circulation
Oleic Acids Lung injury Lesion chemistry.chemical_compound Dogs medicine Distribution (pharmacology) Animals Radiology Nuclear Medicine and imaging Respiratory system Fat embolism Particle Size Radionuclide Imaging Lung business.industry General Medicine medicine.disease Microspheres Oleic acid medicine.anatomical_structure chemistry Cesium Radioisotopes Strontium Radioisotopes Particle size medicine.symptom Nuclear medicine business Pulmonary Embolism Oleic Acid |
| Zdroj: | Investigative radiology. 21(8) |
| ISSN: | 0020-9996 |
| Popis: | Oleic acid infusion, as a model of fat embolism, produces a predominantly peripheral lesion in the dog lung. The lung injury corresponds to the peripheral distribution of labeled oleic acid. The basis for this distribution of oleic acid is not known. Our hypothesis for this nonuniform distribution is that particle diameter plays a role in the subsequent distribution of infused oleic acid and the resulting lung injury. We injected 15-mu microspheres /sup 85/Sr and then 137-mu microspheres (/sup 141/Ce) into the right atria of seven dogs, which were killed and the lungs removed. Analysis of the distribution of the two different diameter microspheres within axial slices from the left caudal lobe of each dog revealed a peripheral distribution of the larger diameter microspheres not seen with the smaller microspheres. |
| Databáze: | OpenAIRE |
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