Hemocompatible Chitin-Chitosan Composite Fibers
| Autor: | Oksana P. Kirichuk, Sergei I. Kuznetzov, Ekaterina N. Maevskaia, Vladimir V. Yudin, E. N. Dresvyanina, Pierfrancesco Morganti |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Aging
Materials science Composite number Pharmaceutical Science 02 engineering and technology Dermatology macromolecular substances 010402 general chemistry chitin 01 natural sciences lcsh:Chemistry Chitosan chemistry.chemical_compound Chitin Ultimate tensile strength Chemical Engineering (miscellaneous) Fiber mechanical characteristics Spinning Sorption hemocompatibility 021001 nanoscience & nanotechnology 0104 chemical sciences carbohydrates (lipids) lcsh:QD1-999 chemistry Chemical engineering Nanofiber Surgery chitosan 0210 nano-technology |
| Zdroj: | Cosmetics Volume 7 Issue 2 Cosmetics, Vol 7, Iss 28, p 28 (2020) |
| ISSN: | 2079-9284 |
| DOI: | 10.3390/cosmetics7020028 |
| Popis: | Composite chitosan fibers filled with chitin nanofibrils (CNF) were obtained by the wet spinning method. The paper discusses the mechanical properties of such type fibers and their hemocompatibility, as well as the possibility of optimizing these properties by adding chitin nanofibrils. It was shown that low CNF concentration (about 0.5%) leads to an increase in fiber tensile strength due to the additional orientation of chitosan macromolecules. At the same time, with an increase in the content of CNF, the stability of the mechanical properties of composite fibers in a humid medium increases. All chitosan fibers, except 0.5% CNF, showed good hemocompatibility, even on prolonged contact with human blood. The addition of chitin nanofibers leads to decrease in hemoglobin molecules sorption due to the decline in optical density at wavelengths of 414 nm and 540 nm. Nevertheless, the hemolysis of fibers was comparable or even lesser that carbon hemosorbent, which is actively used in clinical practice. |
| Databáze: | OpenAIRE |
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