Influence of the CYP4F2 polymorphism on the risk of hemorrhagic complications in coumarin-treated patients
| Autor: | Ye-Qi Sun, Rong Li, Peng Chen, Jie Pan, Guo-Ping Yang, Yu-Sheng Zhou |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
CYP4F2 lcsh:Medicine Hemorrhage 030204 cardiovascular system & hematology Lower risk 03 medical and health sciences 0302 clinical medicine Coumarins Internal medicine Statistical significance medicine Humans Cytochrome P450 Family 4 International Normalized Ratio 030212 general & internal medicine Polymorphism Genetic business.industry lcsh:R Anticoagulants General Medicine Odds ratio Confidence interval Surgery Relative risk Hemorrhagic complication Inclusion and exclusion criteria Systematic Review business |
| Zdroj: | Saudi Medical Journal, Vol 37, Iss 4, Pp 361-368 (2016) Saudi Medical Journal |
| ISSN: | 1658-3175 0379-5284 |
| Popis: | Objectives: To evaluate the impact of the CYP4F2 polymorphism on bleeding complications and over-anticoagulation due to coumarin. Methods: A comprehensive literature search was performed to look for eligible studies published prior to February 2015 in EMBASE and PubMed. References were strictly identified by inclusion and exclusion criteria, and authors of primary studies were consulted for additional information and data. Revman 5.3 software was used to analyze the impact of the CYP4F2 polymorphism on hemorrhagic complications and over-anticoagulation events (international normalized ratio greater than 4). Results: Eight studies involving 3,101 samples met the specified inclusion criteria. Compared with wild-type homozygotes (CYP4F2*1*1), carriers of the CYP4F2*3 variant had no significant effects on total bleeding events (odds ratio [OR]: 0.86; 95% confidence interval [CI]: 0.71-1.05; p =0.15), major hemorrhage complications in coumarin users (OR: 0.80; 95% CI: 0.64-1.01; p =0.06). Patients carried CYP4F2*3 also had nonsignificant associations with the risk of over-anticoagulation (relative risk [RR]: 079; 95% CI: 0.59-1.06; p =0.12). We found a lower risk in patients with homozygotes for CYP4F2*3, but there was no statistical significance (RR: 0.66; 95% CI: 0.43-1.01; p =0.05). Conclusion: This meta-analysis indicated the impact of the CYP4F2 polymorphism on bleeding complications and over-anticoagulation in coumarin-treated patients failed to reach the level of statistical significance. However, large-scale and well designed studies are necessary to determine conclusively the association between the CYP4F2 polymorphism and hemorrhage risk. Saudi Med J 2016; Vol. 37 (4): 361-368 doi: 10.15537/smj.2016.4.14036 How to cite this article: Chen P, Sun YQ, Yang GP, Li R, Pan J, Zhou YS. Influence of the CYP4F2 polymorphism on the risk of hemorrhagic complications in coumarin-treated patients. Saudi Med J 2016; 37: 361-368. |
| Databáze: | OpenAIRE |
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