Natural Products as Anticancerous Therapeutic Molecules with Special Reference to Enzymatic Targets Topoisomerase, COX, LOX and Aromatase
| Autor: | Manika Awasthi, Veda P. Pandey, Upendra N. Dwivedi, Swati Singh |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Drug 030103 biophysics Quantitative structure–activity relationship media_common.quotation_subject Lipoxygenase Quantitative Structure-Activity Relationship Pharmacology Biochemistry 03 medical and health sciences Aromatase Neoplasms Drug Discovery medicine Animals Anticarcinogenic Agents Humans Molecular Targeted Therapy Enzyme Inhibitors Molecular Biology media_common chemistry.chemical_classification Biological Products biology Topoisomerase Cancer Cell Biology General Medicine Plants medicine.disease Antineoplastic Agents Phytogenic Multiple drug resistance Enzyme chemistry Prostaglandin-Endoperoxide Synthases biology.protein DNA Topoisomerases Plant Sources |
| Zdroj: | Current Protein & Peptide Science. 19 |
| ISSN: | 1389-2037 |
| DOI: | 10.2174/1389203718666170106102223 |
| Popis: | Cancer, characterized by uncontrolled growth and proliferation of cells, is affecting millions of people every year and estimated as the second leading cause of death. Its successful treatment yet remains a challenge due to the lack of selectivity, toxicity and the development of multidrug resistant cells to the currently available drugs. Plant derived natural products hold great promise for discovery and development of new pharmaceuticals against cancer as evident by the fact that out of 121 drugs prescribed for cancer treatment till date, 90 are derived from plant sources. Furthermore, the plant derived therapeutic molecules are also considered as safer substitutes to those of synthetic ones. In this review, the therapeutic potentials of plant derived natural products belonging to secondary metabolites, namely alkaloids, flavonoids and terpenoids as anticancer molecules, involving various strategies of treatment, have been discussed with special reference to topoisomerases (Topo), cyclooxygenases (COX), lipoxygenase (LOX) and aromatase as enzymatic targets for various types of cancers. Furthermore, in view of the recent advances made in the field of computer aided drug design, the present review also discusses the use of computational approaches such as ADMET, molecular docking, molecular dynamics simulation and QSAR to assess and predict the safety, efficacy, potency and identification of such potent anticancerous therapeutic molecules. |
| Databáze: | OpenAIRE |
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