Intravital NIR-II three-dimensional photoacoustic imaging of biomineralized copper sulfide nanoprobes
| Autor: | Yuejun Lin, Zonghai Sheng, Huichao Zhou, Jie Ren, Dehong Hu, Hairong Zheng, Tinghui Yin, Duyang Gao, Chen Qiu, Rongqin Zheng, Xin Liu, Chengbo Liu, Xiaoyan Miao |
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| Rok vydání: | 2021 |
| Předmět: |
Male
Biodistribution Infrared Rays Biomedical Engineering Photoacoustic imaging in biomedicine Sulfides Photoacoustic Techniques chemistry.chemical_compound Mice Deep tissue In vivo Tumor Cells Cultured Animals Humans General Materials Science Particle Size Fluorescent Dyes Mice Inbred BALB C technology industry and agriculture Prostatic Neoplasms General Chemistry General Medicine Neoplasms Experimental Copper sulfide HEK293 Cells chemistry In vivo biodistribution Nanoparticles Copper Biomedical engineering |
| Zdroj: | Journal of materials chemistry. B. 9(13) |
| ISSN: | 2050-7518 |
| Popis: | Photoacoustic (PA) imaging with functional nanoprobes in the second near-infrared region (NIR-II, 1000–1700 nm) has aroused much interest due to its deep tissue penetration and high maximum laser permissible exposure. However, most NIR-II PA imaging is performed using the two-dimensional (2D) imaging modality, which impedes the comprehension of the in vivo biodistribution, angiography and molecular-targeted performance of NIR-II nanoprobes (NPs). Herein, we report the systematic monitoring of biomineralized copper sulfide (CuS) NPs, typical NIR-II NPs, in mouse models by employing NIR-II three-dimensional (3D) PA imaging. The advanced imaging modality provides dynamic information about the 3D biodistribution and metabolic pathway of CuS NPs. We also achieved contrast-enhanced 3D PA imaging of abdominal and cerebral vessels at a high signal-to-background ratio. Moreover, the tumor-targeted CuS NPs conjugated with the bombesin peptide endowed NIR-II 3D PA with superior performance in imaging orthotopic tumors both deep in the prostate and in the brain beneath the intact scalp and skull. Our results highlight the potential of NIR-II 3D PA imaging for the evaluation of the in vivo behavior of NPs, thus providing a promising strategy for screening NPs in clinical translational studies. |
| Databáze: | OpenAIRE |
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