Probiotic/Synbiotic Treatment and Postoperative Complications in Colorectal Cancer Patients: Systematic Review and Meta-analysis of Randomized Controlled Trials
| Autor: | Prudence R. Carr, Efrat L. Amitay, Anton Gies, Dana Clarissa Laetsch, Hermann Brenner |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Synbiotics Review Article Perioperative Care law.invention 03 medical and health sciences 0302 clinical medicine Postoperative Complications Randomized controlled trial Quality of life law Internal medicine medicine Humans Colectomy Randomized Controlled Trials as Topic Proctectomy business.industry Incidence (epidemiology) Incidence Probiotics Gastroenterology Odds ratio Perioperative Clinical trial Treatment Outcome 030220 oncology & carcinogenesis Meta-analysis Quality of Life 030211 gastroenterology & hepatology business Colorectal Neoplasms |
| Zdroj: | Clinical and Translational Gastroenterology |
| ISSN: | 2155-384X |
| Popis: | Colorectal cancer (CRC) is a leading cause of morbidity and mortality. Post-CRC resection complications and lower quality of life (QoL) are associated with a lower long-term survival. Perioperative administration of probiotics/synbiotics might lower prevalence of side effects and improve QoL and survival among CRC patients. Medline, Web of Science, Cochrane database, Embase, and clinical trials registries were searched in January 2020. Altogether, 16 randomized placebo-controlled probiotic/synbiotic clinical trials that included patients undergoing CRC surgery and investigated postoperative complications and QoL side effects were found. Meta-analyses using random-effects model were performed on data from 11 studies to calculate the effects of probiotics/synbiotics on common CRC resection postoperative side effects and complications. Perioperative probiotics/synbiotics administration was associated with lower infection incidence (odds ratio [OR] = 0.34, P < 0.001), lower diarrheal incidence (OR = 0.38, P < 0.001), faster return to normal gut function (mean difference [MD] -0.66 days, P < 0.001), shorter postoperative antibiotics use (MD -0.64 days, P < 0.001), lower incidence of septicemia (OR = 0.31, P < 0.001), and shorter length of hospital stay (MD -0.41 days, P = 0.110). The results support the hypothesis that short-term perioperative administration of probiotics/synbiotics, which are easy to administer, have few side-effects, and are low cost compared with alternatives, might help to alleviate gastrointestinal symptoms and postoperative complications among CRC patients. |
| Databáze: | OpenAIRE |
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