New Delhi Metallo-Beta-Lactamase Facilitates the Emergence of Cefiderocol Resistance in Enterobacter cloacae

Autor:	Dennis Nurjadi, Kaan Kocer, Quan Chanthalangsy, Sabrina Klein, Klaus Heeg, Sébastien Boutin
Rok vydání:	2022
Předmět:	Pharmacology Infectious Diseases Drug Resistance Multiple Bacterial Enterobacter cloacae polycyclic compounds Pharmacology (medical) Microbial Sensitivity Tests biochemical phenomena metabolism and nutrition bacterial infections and mycoses beta-Lactamases Anti-Bacterial Agents Cephalosporins
Zdroj:	Antimicrobial Agents and Chemotherapy. 66
ISSN:	1098-6596 0066-4804
DOI:	10.1128/aac.02011-21
Popis:	Cefiderocol is a promising novel siderophore cephalosporin for the treatment of multidrug-resistant Gram-negative bacilli and with stability against degradation by metallo-β-lactamases. Nonetheless, the emergence of cefiderocol in metallo-β-lactamase-producing Enterobacterales during therapy has been reported on more than one occasion. To understand the underlying mechanisms and factors facilitating the resistance development, we conducted an
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50ae73c1a9f22face4562c58a7b2ffb9 https://doi.org/10.1128/aac.02011-21 Zobrazit plný text záznamu