Identification of two functional forms of immunoglobulin G3-binding protein expressed by group A streptococci
| Autor: | R. A. Otten, Michael D.P. Boyle, Roberta Raeder, T. D. Pack |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
biology
Streptococcus pyogenes Myeloma protein Binding protein Receptors IgG Immunology medicine.disease_cause Microbiology Molecular biology Immunoglobulin G Myeloma Proteins Infectious Diseases Bacterial Proteins Biotinylation Protein A/G biology.protein medicine Animals Humans Parasitology Protein G Antibody Research Article |
| Zdroj: | Infection and Immunity. 62:2104-2107 |
| ISSN: | 1098-5522 0019-9567 |
| Popis: | Analysis of group A streptococcal immunoglobulin G (IgG)-binding protein reactivity with different human IgG3-myeloma proteins provided evidence for at least two functional forms of these molecules. Representative IgG3-binding molecules were isolated, biotinylated, and used as tracers in competitive binding assays. Cross-inhibition studies demonstrated the existence of two distinct patterns of IgG3-binding activity. Proteins of one form could be inhibited from binding to an IgG3-myeloma protein by streptococcal protein G while binding of the second form was not inhibited. These studies further underscore the extent of heterogeneity among immunoglobulin-binding proteins expressed by group A streptococci. |
| Databáze: | OpenAIRE |
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