BN 80927: A novel homocamptothecin with inhibitory activities on both topoisomerase I and topoisomerase II

Autor:	Olivier Lavergne, Alain Rolland, Christophe Lanco, Laurence Lesueur-Ginot, Marion Huchet, Dennis Bigg, Danièle Demarquay, Hélène Coulomb, Jeremiah Harnett
Rok vydání:	1999
Předmět:	Clinical Biochemistry Pharmaceutical Science Antineoplastic Agents Biochemistry chemistry.chemical_compound DU145 Drug Discovery Tumor Cells Cultured Humans Topoisomerase II Inhibitors Enzyme Inhibitors Cytotoxicity neoplasms Molecular Biology chemistry.chemical_classification biology Chemistry Topoisomerase Organic Chemistry Biological activity Enzyme Enzyme inhibitor Cell culture biology.protein Molecular Medicine Camptothecin Drug Screening Assays Antitumor Topoisomerase I Inhibitors DNA
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 9:2599-2602
ISSN:	0960-894X
DOI:	10.1016/s0960-894x(99)00428-x
Popis:	BN 80927, a novel homocamptothecin derivative, inhibits both topoisomerase I and topoisomerase II mediated DNA relaxation and shows pronounced cytotoxicity against HT29, SKOV-3, DU145 and MCF7 human tumor cell lines.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::509d0222579727f64bca61d8645c5fc3 https://doi.org/10.1016/s0960-894x(99)00428-x Zobrazit plný text záznamu Full Text from ScienceDirect