Glutathione and cysteine in HIV-infected hemophiliacs
| Autor: | R.M.Segura Cardona, J M Tusell Puigbert, J.C. Juárez Giménez, M.A.Arbós Via, J. B. Montoro Ronsano, RM López Galera, C. Altisent Roca |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Adult
Male Adolescent Lymphocyte Clinical Biochemistry Biology Hemophilia A Biochemistry chemistry.chemical_compound Immunopathology Blood plasma HIV Seropositivity medicine Humans Cysteine Acquired Immunodeficiency Syndrome Glutathione Disulfide Biochemistry (medical) virus diseases General Medicine Glutathione Middle Aged medicine.anatomical_structure chemistry Immunology Disease Progression Glutathione disulfide Female Viral disease CD8 |
| Zdroj: | Clinica chimica acta; international journal of clinical chemistry. 254(1) |
| ISSN: | 0009-8981 |
| Popis: | A cross-sectional study was designed to determine whether plasma concentrations of glutathione and cysteine in HIV-infected hemophiliacs vary according to the progression of the disease and to compare them with those obtained in HIV negative hemophiliacs. Cysteine, total glutathione and glutathione disulphide were measured in plasma of HIV-infected hemophiliacs at different stages of HIV infection and in plasma of HIV-negative hemophiliacs. CD4 and CD8 T-cell counts, leukocyte and lymphocyte counts, beta 2-microglobulin and p24 antigen values were recorded for HIV positive hemophiliacs at the time of the study. The hemophiliac HIV-positive group showed a decrease in total glutathione levels (-18%) and an increase of glutathione disulphide (8.18 vs. 14.90%) compared to the HIV-negative group. The cysteine levels found in HIV-positive hemophiliacs were not different from those found in the HIV-negative group. There were no differences with statistical significance in total glutathione, glutathione disulphide and cysteine among HIV-infected hemophiliacs according to the different clinical stage of the disease (AIDS vs. non-AIDS). The interest of evaluating plasma concentrations of glutathione and cysteine in HIV-infected patients is limited from the point of view of considering them as markers of progression of the disease. Interest in a therapeutic strategy designed to replenish or normalize glutathione plasma levels is also limited. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect