Assessment of safety and efficacy of antimicrobial photodynamic therapy for peri-implant disease
| Autor: | Mika Sato, Hideyuki Yamamoto, Seigo Ohba, Kazuhiro Egahira, Sawako Noda, Izumi Asahina |
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| Rok vydání: | 2020 |
| Předmět: |
Peri-implantitis
medicine.medical_specialty Combination therapy medicine.medical_treatment 030303 biophysics Biophysics Photodynamic therapy Dermatology 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine polycyclic compounds medicine Humans Pharmacology (medical) Tolonium Chloride Saline Dental Implants 0303 health sciences Photosensitizing Agents business.industry Incidence (epidemiology) Antimicrobial Peri-Implantitis eye diseases Surgery Anti-Bacterial Agents Exact test Oncology Photochemotherapy business Complication therapeutics |
| Zdroj: | Photodiagnosis and photodynamic therapy. 31 |
| ISSN: | 1873-1597 |
| Popis: | Background There is no reliable treatment procedure for peri-implant disease, despite the rise in its incidence. This study sought to evaluate the short-term safety and efficacy of antimicrobial photodynamic therapy (a-PDT) on peri-implantitis by assessing the volume of pus discharge after a-PDT. Methods Patients with pus discharge from a peri-implant pocket were recruited from December 1st, 2019 to April 30th, 2020. The enrolled implants were randomly assigned to one of two groups, the irrigation and a-PDT groups. Their peri-implant pocket was irrigated with normal saline in the irrigation group, and a saline irrigation and subsequent a-PDT with toluidine blue (TB) was performed in the a-PDT group. The safety and efficacy of a-PDT were assessed 7 days after treatment. Results Twenty-five implants in 21 patients (irrigation group; 13 implants, a-PDT group; 12 implants) were registered. No complication was observed after a-PDT. Pus discharge was decreased in 7 of 12 implants (58.3 %) in the a-PDT group, and in 2 of 13 implants (15.4 %) in the irrigation group. According to Fisher’s exact test, a-PDT resulted in a statistically significant decrease in pus discharge compared to irrigation alone (p = 0.0414). Conclusions a-PDT was confirmed to be a safe treatment for peri-implantitis, and the short-term efficacy of a-PDT with TB on peri-implantitis was clarified. Nevertheless, its efficacy remains restricted, and a new combination therapy of a-PDT and decontamination procedures is expected to be developed in future. |
| Databáze: | OpenAIRE |
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