Association between the Mediterranean Diet and Metabolic Syndrome with Serum Levels of miRNA in Morbid Obesity
| Autor: | Sara García-Serrano, Silvia Álvarez-Cubela, María I Fontalba-Romero, Maria Teresa Labajos-Manzanares, Eva García-Escobar, Ricardo L. Pastori, Gemma Rojo, Juan Domínguez-Bendala, Ana Lago-Sampedro, Eduardo García-Fuentes, Sergio Valdés, Soledad Lopez-Enriquez |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Male
Mediterranean diet White meat type 2 diabetes mellitus Physiology lcsh:TX341-641 Type 2 diabetes Diet Mediterranean Diet Surveys Article Morbid obesity chemistry.chemical_compound Eating microRNA medicine Humans miRNA Metabolic Syndrome Nutrition and Dietetics Triglyceride business.industry Incidence Type 2 Diabetes Mellitus Cardiometabolic Risk Factors Middle Aged medicine.disease Obesity Morbid morbid obesity MicroRNAs chemistry Diabetes Mellitus Type 2 Patient Compliance Female Metabolic syndrome business lcsh:Nutrition. Foods and food supply Food Science |
| Zdroj: | Nutrients Volume 13 Issue 2 Nutrients, Vol 13, Iss 436, p 436 (2021) |
| ISSN: | 2072-6643 |
| Popis: | Background: The Mediterranean diet (MD) could be involved in the regulation of different miRNAs related to metabolic syndrome (MS). Methods: We analyzed the serum level of mir-let7a-5p, mir-21, mir-590, mir-107 and mir-192 in patients with morbid obesity and its association with the MD and MS. Results: There is an association between the adherence to MD and higher serum levels of mir-590. Mir-590 was lower in those patients who consumed > 2 commercial pastries/week. Mir-let7a was lower in those who consumed ≥1 sweetened drinks, in those who consumed ≥3 pieces of fruit/day and in those who consumed less red than white meat. A lower mir-590 and mir-let7a, and a higher mir-192 level, were found in patients who met the high-density lipoprotein cholesterol (HDL) criterion of MS. A higher mir-192 was found in those patients who met the triglyceride criterion of MS and in those with type 2 diabetes (T2DM). Conclusions: There is an association between specific serum levels of miRNAs and the amount and kind of food intake related to MD. Mir-590 was positively associated with a healthy metabolic profile and type of diet, while mir-192 was positively associated with a worse metabolic profile. These associations could be suggestive of a possible modulation of these miRNAs by food. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|