Efficient Removal of Albumin-Bound Furancarboxylic Acid, an Inhibitor of Erythropoiesis, by Continuous Ambulatory Peritoneal Dialysis
| Autor: | Kenji Maeda, Yasuo Uehara, Kazumasa Yamada, Tomio Kodama, Tomoko Yazawa, Toshimitsu Niwa |
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| Rok vydání: | 1990 |
| Předmět: |
Adult
Male medicine.medical_specialty Anemia medicine.medical_treatment Urology Kidney urologic and male genital diseases Peritoneal dialysis Colony-Forming Units Assay Peritoneal Dialysis Continuous Ambulatory Albumins medicine Humans Erythropoiesis Furans Chromatography High Pressure Liquid Aged Uremia business.industry Continuous ambulatory peritoneal dialysis Albumin Kidney metabolism Middle Aged medicine.disease female genital diseases and pregnancy complications Surgery Female Hemodialysis Propionates business |
| Zdroj: | Nephron. 56:241-245 |
| ISSN: | 2235-3186 1660-8151 |
| DOI: | 10.1159/000186147 |
| Popis: | 3-Carboxy-4-methyl-5-propyl-2-furanpropionic acid, which cannot be removed by conventional hemodialysis due to its strong albumin binding, was found to be efficiently removed by continuous ambulatory peritoneal dialysis (CAPD), resulting in a lower serum level in uremic patients on CAPD than in those on hemodialysis. 3-Carboxy-4-methyl-5-propyl-2-furanpropionic acid was demonstrated in vitro to inhibit erythroid colony formation. The anemia in patients on CAPD was significantly less severe than in those on hemodialysis. These results suggest that the efficient removal by CAPD of 3-carboxy-4-methyl-5-propyl-2-furanpropionic acid, an inhibitor of erythropoiesis, is related to an improvement of anemia in patients on CAPD. |
| Databáze: | OpenAIRE |
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