Nanocomposites based on Soluplus and Angelica gigas Nakai extract fabricated by an electrohydrodynamic method for oral administration
| Autor: | Jae Young Jeong, Wie-Soo Kang, Jae-Young Lee, Ju-Hwan Park, In-Soo Yoon, Dae-Duk Kim, Jeong-Jun Lee, Hyun-Jong Cho, Suyeong Nam, Song Yi Lee |
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| Rok vydání: | 2016 |
| Předmět: |
Male
Absorption (pharmacology) Analytical chemistry Administration Oral 02 engineering and technology Plant Roots 030226 pharmacology & pharmacy Nanocomposites Rats Sprague-Dawley Biomaterials 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Colloid and Surface Chemistry Oral administration Decursinol angelate Animals Benzopyrans Angelica Ethanol Nanocomposite Aqueous solution biology Aqueous medium Plant Extracts Chemistry Electrochemical Techniques Hydrogen-Ion Concentration 021001 nanoscience & nanotechnology biology.organism_classification Rats Surfaces Coatings and Films Electronic Optical and Magnetic Materials Butyrates Angelica gigas Liver Hydrodynamics 0210 nano-technology |
| Zdroj: | Journal of Colloid and Interface Science. 484:146-154 |
| ISSN: | 0021-9797 |
| DOI: | 10.1016/j.jcis.2016.08.080 |
| Popis: | Nanocomposites (NCs) based on Soluplus (SP) were fabricated by an electrohydrodynamic (EHD) method for the oral delivery of Angelica gigas Nakai (AGN). Nano-sized particles were obtained after dispersing the resultant, produced by the EHD technique, in the aqueous environment. AGN/SP2 (AGN:SP=1:2, w/w) NC dispersion in aqueous media exhibited a 130nm mean diameter, narrow size distribution, and robust stability in the tested concentration range of the ethanol extract of AGN (AGN EtOH ext) and at pH 1.2 and 6.8. Amorphization of the components of AGN and their interactions with SP in the AGN/SP2 NC formulation were demonstrated by X-ray diffractometry (XRD) analysis. The released amounts of decursin (D) and decursinol angelate (DA), major components of AGN, from NCs were improved compared with those from the AGN EtOH ext group at both pH 1.2 and 6.8. As D and DA can be metabolized into decursinol (DOH) in the liver after oral administration, the DOH concentrations in plasma were quantitatively determined to evaluate the oral absorption of AGN. In a pharmacokinetic study in rats, higher oral absorption and the maximum concentration in plasma (Cmax) were presented in the AGN/SP2 NC group compared with the AGN EtOH ext and AGN NC groups. These findings indicate the successful application of developed SP-based NCs for the oral delivery of AGN. |
| Databáze: | OpenAIRE |
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