Human gut endogenous proteins as a potential source of angiotensin-I-converting enzyme (ACE-I)-, renin inhibitory and antioxidant peptides
Autor: | Shane M. Rutherfurd, Maria Hayes, Paul J. Moughan, Carlos A. Montoya, Lakshmi A. Dave |
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Rok vydání: | 2016 |
Předmět: |
0301 basic medicine
Physiology Angiotensin-Converting Enzyme Inhibitors Peptide Endogeny Peptidyl-Dipeptidase A Biology Gut flora Biochemistry Antioxidants 03 medical and health sciences Cellular and Molecular Neuroscience Endocrinology Renin Animals Humans chemistry.chemical_classification 030109 nutrition & dietetics Mucin biology.organism_classification Blood proteins Gastrointestinal Microbiome Gastrointestinal Tract 030104 developmental biology Enzyme Secretory protein chemistry Peptides Digestion |
Zdroj: | Peptides. 76:30-44 |
ISSN: | 0196-9781 |
Popis: | It is well known that endogenous bioactive proteins and peptides play a substantial role in the body's first line of immunological defence, immune-regulation and normal body functioning. Further, the peptides derived from the luminal digestion of proteins are also important for body function. For example, within the peptide database BIOPEP (http://www.uwm.edu.pl/biochemia/index.php/en/biopep) 12 endogenous antimicrobial and 64 angiotensin-I-converting enzyme (ACE-I) inhibitory peptides derived from human milk and plasma proteins are listed. The antimicrobial peptide database (http://aps.unmc.edu/AP/main.php) lists over 111 human host-defence peptides. Several endogenous proteins are secreted in the gut and are subject to the same gastrointestinal digestion processes as food proteins derived from the diet. The human gut endogenous proteins (GEP) include mucins, serum albumin, digestive enzymes, hormones, and proteins from sloughed off epithelial cells and gut microbiota, and numerous other secreted proteins. To date, much work has been carried out regarding the health altering effects of food-derived bioactive peptides but little attention has been paid to the possibility that GEP may also be a source of bioactive peptides. In this review, we discuss the potential of GEP to constitute a gut cryptome from which bioactive peptides such as ACE-I inhibitory, renin inhibitory and antioxidant peptides may be derived. |
Databáze: | OpenAIRE |
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