Antibody responses induced by long-term vaccination with an octovalent conjugatePseudomonas aeruginosavaccine in children with cystic fibrosis
| Autor: | Martin H. Schoeni, Paul Marcus, Alois B. Lang, Anna Ruedeberg, Urs B. Schaad, John U. Que, Adrian W. Zuercher, Michael P. Horn |
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| Rok vydání: | 2006 |
| Předmět: |
Adult
Male Microbiology (medical) Adolescent Cystic Fibrosis Immunology Antibody Affinity Exotoxins medicine.disease_cause Microbiology Cystic fibrosis Immunoglobulin G Serology Epitopes Conjugate vaccine medicine Humans Immunology and Allergy Pseudomonas Infections Child Retrospective Studies Antigens Bacterial biology Pseudomonas aeruginosa Infant General Medicine medicine.disease Vaccination Infectious Diseases Immunization Child Preschool Bacterial Vaccines biology.protein Female Antibody |
| Zdroj: | FEMS Immunology & Medical Microbiology. 47:302-308 |
| ISSN: | 1574-695X 0928-8244 |
| Popis: | We assessed the serological responses over 10 years to repeated immunization of cystic fibrosis (CF) patients with an O-polysaccharide (OPS)-toxin A conjugate vaccine against Pseudomonas aeruginosa. A retrospective analysis was performed with sera from 25 vaccinated and 25 unvaccinated children treated at the same CF centre and matched for clinical management, age and gender. Yearly immunization led to sustained elevations of serum immunoglobulin G (IgG) antibody levels to all vaccine components. Eighteen unvaccinated patients but only eight vaccinated ones developed chronic pseudomonal lung infections. Infection rapidly caused further marked elevations of polysaccharide- but not toxin A-specific serum IgG in both immunized and nonimmunized patients, indicating that protection did not depend on the quantity of IgG present. However, qualitative analyses revealed that the protective capacity of specific serum IgG antibodies was linked to high affinity and to specificity for OPS serotypes rather than for lipopolysaccharide core epitopes. |
| Databáze: | OpenAIRE |
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