Prevalence estimates of diabetes in pregnancy in a rural, sub-Saharan population
| Autor: | Sophie E. Moore, Andrew M. Doel, Robin M. Bernstein, Alice A. Maidwell-Smith |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Blood Glucose
Rural Population Endocrinology Diabetes and Metabolism Disease Cohort Studies 0302 clinical medicine Endocrinology Pregnancy Prevalence 030212 general & internal medicine IADPSG International Association of Diabetes in Pregnancy Study Group HIP Hyperglycaemia in Pregnancy DIP Diabetes in Pregnancy Gestational diabetes education.field_of_study Obstetrics General Medicine Fasting Cohort Gestation Female Gambia SPSS Statistical Package for the Social Sciences Adult medicine.medical_specialty Adolescent Population 030209 endocrinology & metabolism Article Veins 03 medical and health sciences Young Adult Diabetes mellitus Internal Medicine medicine IDF International Diabetes Federation Humans education HERO-G Hormonal and Epigenetic Regulators of Growth Trial Africa South of the Sahara business.industry OGTT Oral Glucose Tolerance Test GDM Gestational Diabetes Mellitus Diabetes in pregnancy Glucose Tolerance Test medicine.disease MRC Medical Research Council The Gambia Capillaries Diabetes Gestational Hyperglycemia HDIP Hyperglycaemia first Detected in Pregnancy business Hyperglycaemia in pregnancy |
| Zdroj: | Diabetes Research and Clinical Practice |
| ISSN: | 1872-8227 |
| Popis: | Aims To determine the prevalence of Hyperglycaemia first Detected in Pregnancy (HDIP) in a cohort of women from rural Gambia and compare the diagnostic ability of capillary blood glucose (CBG) sampling to identify HIP versus laboratory-based analysis of venous plasma glucose (VPG). Methods Pregnant women from rural Gambia (N = 251) underwent a 75 g Oral Glucose Tolerance Test (OGTT) at 28-weeks of gestation. Gestational Diabetes Mellitus was assessed as fasting glucose concentration ≥ 5.1–6.9 mmol/L; ≥10.0 mmol/L at 1-h post load; or ≥ 8.5 mmol/L at 2-h post load and Diabetes in Pregnancy as fasting glucose > 7.0 mmol/L. Results A total of 199 and 244 women had VPG and CBG measurements respectively, and 198 women had both. 32 women (16.1%) were diagnosed with HDIP using VPG, mostly based on fasting concentrations. Conclusions The prevalence of HDIP in rural Gambia was higher than anticipated, emphasising a need for maternal diabetic policy. Based on the current findings, tailored recommendations could include measuring fasting VPG alone when conducting a full OGTT is not feasible. Similarly, CBG may be of value for excluding disease and thereby limiting costly laboratory-based investigations to a select few. |
| Databáze: | OpenAIRE |
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