Selective anti-cancer activity against melanoma cells using 3-O-acetyl-β-boswellic acid-loaded 3D-Printed scaffold
| Autor: | Fatemeh Jamshidi-adegani, Saeid Vakilian, Sulaiman Al-Hashmi, Juhaina Al-Kindi, Najeeb Ur Rehman, Yaqeen Al-Sinani, Shokoofeh Ghaemi, Khurshid Alam, Muhammad U. Anwar, Rene Csuk, Ahmed Al-Harrasi |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Natural Product Research. 37:2049-2054 |
| ISSN: | 1478-6427 1478-6419 |
| DOI: | 10.1080/14786419.2022.2116024 |
| Popis: | This study aimed to develop a local 3 D-printed bioactive graft using poly-caprolacton (PCL) as a drug carrier and 3-O-acetyl-β-boswellic acid (β-ABA) as an anticancer compound. β-ABA-loaded 3 D-printed scaffold was fabricated and physically characterized. The results indicated more desirable mechanical and physical properties of the β-ABA-loaded PCL mat in comparison with the PCL scaffold. Following sustained release of β-ABA, the β-ABA-loaded PCL scaffold revealed selective cytotoxic activity against melanoma cells, while the PCL + ABA with the bolus delivery of β-ABA was toxic against fibroblast cells. Followed by the induction of apoptosis in melanoma cells at the gene level, the result of the western blot showed that the β-ABA-loaded scaffold significantly up-regulated P53 and down-regulated BCL2, with an increment in the ratio of Bax/BCL2. The selective anti-cancer properties of β-ABA-loaded 3 D printed scaffold against melanoma cells indicated that this scaffold could be potentially used as a bioactive graft to improve the melanoma treatment. |
| Databáze: | OpenAIRE |
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