Vitamin D Status Impacts Genital Mucosal Immunity and Markers of HIV-1 Susceptibility in Women
| Autor: | Christiane Rollenhagen, Sharon Anderson, Andrea R. Thurman, Nikolas C. Vann, Neelima Chandra, Suzanne S. Jackson, Susana N. Asin, Jason Daniels, Mimi Ghosh, Gustavo F. Doncel, Meredith R. Clark |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Vitamin Adult Cell Physiology Nutritional Status lcsh:TX341-641 HIV Infections Pilot Projects vitamin D deficiency Article HIV-1 susceptibility 03 medical and health sciences chemistry.chemical_compound Young Adult 0302 clinical medicine Immune system medicine Vitamin D and neurology vitamin D supplementation Humans Immunologic Factors Sex organ 030212 general & internal medicine Vitamin D 25-Hydroxyvitamin D 2 Nutrition and Dietetics Mucous Membrane business.industry immune regulation Immune regulation Genitalia Female Middle Aged medicine.disease Vitamin D Deficiency 030104 developmental biology medicine.anatomical_structure chemistry Dietary Supplements HIV-1 Female Disease Susceptibility business lcsh:Nutrition. Foods and food supply Ex vivo Food Science |
| Zdroj: | Nutrients Nutrients, Vol 12, Iss 3176, p 3176 (2020) Volume 12 Issue 10 |
| ISSN: | 2072-6643 |
| Popis: | While vitamin D insufficiency is known to impact a multitude of health outcomes, including HIV-1, little is known about the role of vitamin D-mediated immune regulation in the female reproductive tract (FRT). We performed a pilot clinical study of 20 women with circulating 25(OH)D levels < 62.5 nmol/L. Participants were randomized into either weekly or daily high-dose oral vitamin D supplementation groups. In addition to serum vitamin D levels, genital mucosal endpoints, including soluble mediators, immune cell populations, gene expression, and ex vivo HIV-1 infection, were assessed. While systemic vitamin D levels showed a significant increase following supplementation, these changes translated into modest effects on the cervicovaginal factors studied. Paradoxically, post-supplementation vitamin D levels were decreased in cervicovaginal fluids. Given the strong correlation between vitamin D status and HIV-1 infection and the widespread nature of vitamin D deficiency, further understanding of the role of vitamin D immunoregulation in the female reproductive tract is important. |
| Databáze: | OpenAIRE |
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