Sodium-23 MRI of whole spine at 3 Tesla using a 5-channel receive-only phased-array and a whole-body transmit resonator
| Autor: | Matthias Malzacher, Raffi Kalayciyan, Lothar R. Schad, Stefan Haneder, Simon Konstandin |
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| Rok vydání: | 2014 |
| Předmět: |
Materials science
Magnetic Resonance Spectroscopy Channel (digital image) Phased array Transducers Biophysics Sensitivity and Specificity Imaging phantom 030218 nuclear medicine & medical imaging 03 medical and health sciences Resonator 0302 clinical medicine Nuclear magnetic resonance medicine Humans Radiology Nuclear Medicine and imaging Tissue Distribution Whole Body Imaging Radiological and Ultrasound Technology medicine.diagnostic_test Phantoms Imaging Reproducibility of Results Magnetic resonance imaging Equipment Design Image Enhancement Magnetic Resonance Imaging Spine Molecular Imaging Equipment Failure Analysis Intervertebral disk Sodium MRI Sodium Isotopes Radiopharmaceuticals Sensitivity (electronics) 030217 neurology & neurosurgery |
| Zdroj: | Zeitschrift fur medizinische Physik. 26(1) |
| ISSN: | 1876-4436 |
| Popis: | Sodium magnetic resonance imaging ( 23 Na MRI) is a unique and non-invasive imaging technique which provides important information on cellular level about the tissue of the human body. Several applications for 23 Na MRI were investigated with regard to the examination of the tissue viability and functionality for example in the brain, the heart or the breast. The 23 Na MRI technique can also be integrated as a potential monitoring instrument after radiotherapy or chemotherapy. The main contribution in this work was the adaptation of 23 Na MRI for spine imaging, which can provide essential information on the integrity of the intervertebral disks with respect to the early detection of disk degeneration. In this work, a transmit-only receive-only dual resonator system was designed and developed to cover the whole human spine using 23 Na MRI and increase the receive sensitivity. The resonator system consisted of an already presented 23 Na whole-body resonator and a newly developed 5-channel receive-only phased-array. The resonator system was first validated using bench top and phantom measurements. A threefold SNR improvement at the depth of the spine (∼7 cm) over the whole-body resonator was achieved using the spine array. 23 Na MR measurements of the human spine using the transmit-only receive-only resonator system were performed on a healthy volunteer within an acquisition time of 10 minutes. A density adapted 3D radial sequence was chosen with 6 mm isotropic resolution, 49 ms repetition time and a short echo time of 540 μs. Furthermore, it was possible to quantify the tissue sodium concentration in the intervertebral discs in the lumbar region (120 ms repetition time) using this setup. |
| Databáze: | OpenAIRE |
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