Long-term outcome of third, fourth and fifth kidney transplantation: technical aspects and immunological challenges
| Autor: | Jürgen Treckmann, Patrizia Halfmann, Dieter P. Hoyer, Gernot M. Kaiser, Sonia Radunz, Tamas Benkö, Anja Gäckler |
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| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
030232 urology & nephrology Medizin graft survival 030230 surgery 03 medical and health sciences 0302 clinical medicine patient survival medicine Kidney transplantation Kidney Transplantation business.industry Incidence (epidemiology) Panel reactive antibody Patient survival kidney retransplantation immunological complications medicine.disease University hospital surgical complications Surgery medicine.anatomical_structure Nephrology Cohort business |
| Zdroj: | Clinical Kidney Journal |
| ISSN: | 2048-8505 |
| Popis: | Background The number of patients on waiting lists for repeated kidney transplantation has increased. However, retransplanted patients have a greater surgical and immunological risk than first-time kidney recipients. Methods We retrospectively analysed all kidney recipients that underwent third, fourth or fifth kidney transplantation (Group 3+) at the University Hospital Essen, Essen, Germany from October 1973 to January 2017. A historical cohort of recipients retransplanted with a second kidney (Group 2) served as the control. Donor and recipient demographic data, cold ischaemia time (CIT), warm ischaemia time, overall operation time and methods, transplantectomy of previous kidney grafts, incidence of surgical and immunological complications as well as patient- and death-censored survival were analysed. Results We identified 108 recipients transplanted with the third, fourth or fifth renal allograft. Patients with more than one transplantation had significantly higher surgical risk due to atherosclerosis (P = 0.002) and higher immunological risk due to higher panel reactive antibody levels preoperatively (current panel reactive antibody P = 0.004; highest panel reactive antibody value P = 0.0001). Group 3+ patients had more often undergone previous transplant nephrectomy (P = 0.0001). There was a significant difference in CIT (P = 0.009), overall operative time (P = 0.0001) and post-transplantation thrombotic events (P = 0.02). We could not demonstrate any differences in graft and patient survival. Conclusion Third, fourth and fifth transplant recipients are a high-risk patient cohort. Our results suggest that patient survival after more than three renal transplantations is similar to that of second graft recipients. This supports the concept of repeated kidney retransplantations. |
| Databáze: | OpenAIRE |
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