Extracapsular spread in oral squamous cell carcinoma
| Autor: | E. David Vaughan, Rebecca Hanlon, Christopher Evans, Gillian L. Hall, James S. Brown, H. Lewis-Jones, Derek Lowe, Simon N. Rogers, Richard Shaw, Julia A. Woolgar |
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| Rok vydání: | 2009 |
| Předmět: |
Male
Oncology medicine.medical_specialty Pathology Kaplan-Meier Estimate Risk Factors Internal medicine Carcinoma Humans Medicine Basal cell Aged medicine.diagnostic_test business.industry Incidence (epidemiology) Head neck Magnetic resonance imaging Prognosis medicine.disease Magnetic Resonance Imaging Immunosurveillance Logistic Models medicine.anatomical_structure Otorhinolaryngology Cervical lymph nodes Lymphatic Metastasis Cohort Carcinoma Squamous Cell Lymph Node Excision Female Mouth Neoplasms Neoplasm Recurrence Local business |
| Zdroj: | Head & Neck. |
| ISSN: | 1097-0347 1043-3074 |
| Popis: | Background Extracapsular spread (ECS) in the cervical lymph nodes represents the most significant adverse prognostic indicator in oral squamous cell carcinoma (OSCC). Methods In a consecutive cohort of OSCC treated by primary surgery, ECS was seen in 25% (101) of 400 patients. Results ECS doubled the incidence of local recurrence and distant metastases, but tripled regional failure. The recurrences occurred sooner in ECS than in non-ECS cases (206 vs 334 days, p = .04). Patients with macroscopic ECS had a 5-year overall survival (OS) of 19% compared with 31% in microscopic ECS. MRI neck staging offered poor sensitivity, especially in microscopic ECS. Age >75 years, smoking, and heavy use of alcohol were independent predictors of ECS, which may implicate a failure of immunosurveillance by the host as much as adverse biology of the tumor. Conclusions Reporting of ECS is essential in accurate prognostication, and we advocate that all patients with OSCC and ECS should be grouped as pN3 on the basis of their prognosis. © 2009 Wiley Periodicals, Inc. Head Neck, 2010 |
| Databáze: | OpenAIRE |
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