Adult mesenchymal stem cells and impaction grafting: a new clinical paradigm shift
Autor: | Andrew M.R. New, Richard O.C. Oreffo, B.J.R.F. Bolland, Douglas G. Dunlop, Simon Tilley |
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Rok vydání: | 2007 |
Předmět: |
medicine.medical_specialty
Scaffold Bone Regeneration Arthroplasty Replacement Hip medicine.medical_treatment Biomedical Engineering Degeneration (medical) Bone grafting Mesenchymal Stem Cell Transplantation Tissue engineering medicine Humans Bone Resorption Bone regeneration Aged Aged 80 and over Hip surgery Bone Transplantation Tissue Engineering business.industry Mesenchymal stem cell Mesenchymal Stem Cells General Medicine Surgery Bone Substitutes Orthopedic surgery business |
Zdroj: | Expert Review of Medical Devices. 4:393-404 |
ISSN: | 1745-2422 1743-4440 |
Popis: | The demographic challenges of an increasingly aging population emphasize the need for innovative approaches to skeletal reconstruction to augment and repair skeletal tissue lost as a consequence of implant loosening, trauma, degeneration or in situations involving revision surgery requiring bone stock. These clinical imperatives to augment skeletal tissue loss have brought mesenchymal stem cells to the fore in combination with the emerging discipline of tissue engineering. To date, impaction bone grafting for revision hip surgery is a recognized technique to reconstitute bone utilizing morselized allograft to provide a good mechanical scaffold, although with little osteoinductive biological potential. This review details laboratory and clinical examples of a paradigm shift in the application of mesenchymal stem cells with allograft to produce a living composite using the principles of tissue engineering. This step change creates a composite that offers a biological and mechanical advantage over the current gold standard of allograft alone. This translation of tissue engineering concepts into clinical practice offers enormous input into the field of bone regeneration and has implications for translation and future change in skeletal orthopedic practice in an increasingly aging population. |
Databáze: | OpenAIRE |
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