OXIDATIVE STRESS AND MALE FERTILITY: MODERN VIEW ON THE PROBLEM
| Autor: | Viktor Onopko, null Онопко, Elena Kirilenko, null Кириленко |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
reactive oxygen species
Infertility antioxidant 030219 obstetrics & reproductive medicine Science 030232 urology & nephrology Physiology Semen Environmental pollution Biology medicine.disease medicine.disease_cause male infertility Male infertility 03 medical and health sciences 0302 clinical medicine medicine oxidative stress Reproductive system Spermatogenesis Oxidative stress Sperm motility |
| Zdroj: | Acta Biomedica Scientifica, Vol 2, Iss 2, Pp 102-108 (2017) |
| ISSN: | 1811-0649 |
| Popis: | Presently, the expressed tendency to deterioration in parameters of semen is noted in the world, at the same time both the quantity of spermatozoa, and their functional properties decrease. The spermatogenesis is a difficult, extremely sensible process of cellular differentiation; the different systems of organism participate in its adjusting. Violations in any links affect the process of spermatogenesis, and finally, affects parameters of semen. This systematic review of the literature analyses recent publications concerning studies of oxidative stress influencing male fertility. The oxidative stress - the very widespread version of pathology, which accompanies and/or is one of key mechanisms in development of many types of reproductive disorders in men. There are three main mechanisms of impaired fertile function of men in the development of oxidative stress: reducing sperm motility, violation of ability of spermatozoa to penetrate into oocyte and spermatozoa DNA damage. The factors promoting its development are numerous: environmental pollution, life style, addictions, stress, diabetes, and varicocele; however, the most frequent reason of development of oxidative stress in reproductive system of men are infectious and inflammatory diseases and antispermal autoimmune processes in a man's urogenital tract. Considering possible participation of free-radical processes in patospermia development, it is worthwhile to use antioxidants in all cases of the man's infertility connected with oxidative stress. |
| Databáze: | OpenAIRE |
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