Inhibition of cell growth and proliferation in human glioma cells and normal human astrocytes induced by 8-Cl-cAMP and tiazofurin
| Autor: | K. Drabek, Milica Pešić, V Pejanovic, C Esler, Pietrzkowski Z, Sabera Ruzdijic |
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| Předmět: |
DNA Replication
Human glioma Cell Survival 8-Bromo Cyclic Adenosine Monophosphate Antineoplastic Agents Apoptosis Biochemistry chemistry.chemical_compound Ribavirin Genetics medicine Tumor Cells Cultured Humans U87 Cells Cultured Dose-Response Relationship Drug Chemistry Cell growth Brain Neoplasms General Medicine DNA Neoplasm Glioma Cell biology Dose–response relationship Cell culture Astrocytes Molecular Medicine Signal transduction Tiazofurin DNA Cell Division medicine.drug Thymidine |
| Zdroj: | Scopus-Elsevier |
| Popis: | 8-Cl-cAMP and tiazofurin (TR) are anti-tumor agents that besides their antiproliferative effect, also induce differentiation of tumor cells. Although, these agents exert a profound effect on the same events of tumor cell life, it is thought that 8-Cl-cAMP and TR act by modulating the signal transduction pathway through distinct mechanisms. We have compared their effect on two human glioma cell lines (U87 MG and U251 MG) and examined if there is selectivity in their action toward normal human astrocytes. |
| Databáze: | OpenAIRE |
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