The Human Homologues of Fim1, Fim2/c-Fms, and Fim3, Three Retroviral Integration Regions Involved in Mouse Myeloblastic Leukemias, Are Respectively Located on Chromosomes 6p23, 5q33, and 3q27
| Autor: | M. S. Gross, S. Guilhot, M. F. de Tand, Nguyen Van Cong, Jean Frézal, Sylvie Gisselbrecht, Brigitte Sola, D Bordereaux, Pierre Tambourin, Serge Fichelson |
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| Přispěvatelé: | Clinique et Unité de Recherches de Génétique Médicale, Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire de Recherche sur les Communications Hormonales, Laboratoire d'Hématologie Expérimentale, Hopital Saint-Louis [AP-HP] (AP-HP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP) |
| Jazyk: | angličtina |
| Rok vydání: | 1989 |
| Předmět: |
Genetic Markers
Macrophage colony-stimulating factor Human Chromosome Somatic cell [SDV]Life Sciences [q-bio] Chromosomal translocation Biology Mice 03 medical and health sciences Colony Stimulate Factor 0302 clinical medicine Sequence Homology Nucleic Acid Proto-Oncogenes Tumor Cells Cultured Genetics medicine Animals Humans Genetics (clinical) 030304 developmental biology Southern blot Recombination Genetic 0303 health sciences Leukemia Experimental Leukemia Base Sequence Chromosome Mapping Chromosome Leukemia Virus medicine.disease Molecular biology Human genetics Chromosome Banding Friend murine leukemia virus Blotting Southern Leukemia Myeloid Acute Haematopoiesis Karyotyping 030220 oncology & carcinogenesis Chromosome 6p23 Chromosomes Human Pair 5 Chromosomes Human Pair 6 Chromosomes Human Pair 3 |
| Zdroj: | Human Genetics Human Genetics, Springer Verlag, 1989, ⟨10.1007/bf00279000⟩ |
| ISSN: | 0340-6717 1432-1203 |
| DOI: | 10.1007/bf00279000⟩ |
| Popis: | International audience; Three mouse genomic domains, Fim1, Fim2, and Fim3, were previously described as proviral integration regions frequently involved in the early stages of myeloblastic leukemogenesis induced in vivo or in vitro by the Friend murine leukemia virus. Fim2 was identified as the 5′ end of the c-Fms, protooncogene, which encodes the receptor of the macrophage colony stimulating factor (Csflr). The functions of Fim1 and Fim3 are not yet known, but these regions are highly conserved among different species. To examine whether these regions could correspond to known human loci involved in genetic alterations specific to some human leukemias, we undertook their chromosomal mapping. The localization of FIM2/c-FMS on 5q33 was confirmed. FIM1 and FIM3 were localized on human chromosomes 6p22.3–p23 and 3q27 respectively. Interestingly, translocations involving these two regions have been described in various hematopoietic malignancies: the t(6;9)(p23;q34) in acute nonlymphocytic leukemias and the 3q26–q28 translocations in a large variety of leukemias. |
| Databáze: | OpenAIRE |
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