Mechanisms of Hepatic Cholestatic Drug Injury
| Autor: | Tea Omanović Kolarić, Vjera Ninčević, Martina Smolić, Robert Smolić, George Y. Wu |
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| Rok vydání: | 2018 |
| Předmět: |
Liver injury
Drug Cholestasis Drug-induced liver injury Hepatology Bile acid Bile duct medicine.drug_class business.industry media_common.quotation_subject Review Article Pharmacology medicine.disease Bile acids Liver disease medicine.anatomical_structure Toxicity medicine Drug-induced liver injury Bile acids Cholestasis Liver function business media_common |
| Zdroj: | Journal of Clinical and Translational Hepatology |
| ISSN: | 2225-0719 |
| Popis: | Drug-induced cholestasis represents a form of drug-induced liver disease that can lead to severe impairment of liver function. Numerous drugs have been shown to cause cholestasis and consequently bile duct toxicity. However, there is still lack of therapeutic tools that can prevent progression to advanced stages of liver injury. This review focuses on the various pathological mechanisms by which drugs express their hepatotoxic effects, as well as consequences of increased bile acid and toxin accumulation in the hepatocytes. |
| Databáze: | OpenAIRE |
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