Benign epithelial oral lesions – association with human papillomavirus
| Autor: | A-R Piña, Adalberto Mosqueda-Taylor, F-S-C Pontes, H-A-R Pontes, J-M Aguirre-Urizar, F-R Pires, O-P Almeida, F-P Fonseca |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Pathology
medicine.medical_specialty Lesion 03 medical and health sciences 0302 clinical medicine Oral and maxillofacial pathology medicine Humans Papillomaviridae General Dentistry Human papillomavirus 16 Oral Medicine and Pathology biology Human papillomavirus 18 business.industry Research Papillomavirus Infections HPV infection virus diseases 030206 dentistry Condyloma Acuminatum CIENCIAS MÉDICAS [UNESCO] medicine.disease biology.organism_classification Koilocyte Otorhinolaryngology Condylomata Acuminata UNESCO::CIENCIAS MÉDICAS Etiology Surgery medicine.symptom business Verruca Vulgaris |
| Zdroj: | Medicina Oral, Patología Oral y Cirugía Bucal Piña, Alicia-Rumayor ; Fonseca, Felipe Paiva ; Corrêa Pontes, Flávia Sirotheau ; Rebelo-Pontes, Hélder-Antônio ; Pires, Fábio-Ramôa ; Mosqueda Taylor, Adalberto ; Aguirre Urízar, José Manuel ; Almeida, Oslei Paes de. Benign epithelial oral lesions ? association with human papillomavirus. En: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, 24 3 2019: 13 RODERIC. Repositorio Institucional de la Universitat de Valéncia instname |
| ISSN: | 1698-6946 1698-4447 |
| Popis: | Background The presence of human papilloma virus in benign oral lesions has been studied by different techniques obtaining extremely variable results. The objective of this study was to determine the presence of human papillomavirus in 83 cases of benign hyperplastic epithelial oral lesions. Material and Methods Eighty-three oral lesions with clinical or histopathological features suggestive of HPV infection were retrieved from the files of four oral pathology services. Demographic data were obtained from patient´s medical charts. All cases had available clinical image, H&E preparations and paraffin blocks with enough tissue for HPV detection by in situ hybridization, and immunohistochemical reactions for Ki67. Results Episomal positivity for wide spectrum HPV was observed in 24% of the cases; most of them (70%) HPV 6/11 positive. HPV 16/18 was not detected. Condyloma acuminatum was the most common lesion associated with HPV (75%), followed by verruca vulgaris (15%), squamous papilloma and multifocal epithelial hyperplasia, 5% each. Koilocytes were identified in all the HPV positive cases. Ki67 showed an abnormal proliferation pattern in 90% of the HPV positive cases; most of them (70%) showing groups of proliferating cells in focal superficial regions, and in 20% positivity was seen almost in the whole thickness of the epithelium. HPV negative cases showed Ki67 positive cells restricted to the basal layer. Conclusions Regarding oral lesions associated with HPV, condyloma is the most common lesion expressing low-risk subtypes. The etiology of squamous papilloma remains controversial as HPV was found in 1.9% of the cases. The identification of koilocytes and the pattern of expression of Ki67 reflect HPV infection and are helpful for classification. Papillary oral lesions not associated to HPV deserve further studies to better clarify its etiology. Key words:Human papillomavirus, condyloma, papilloma. |
| Databáze: | OpenAIRE |
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