Autor: |
Brian J. Murphy, Melissa Kung, Fucheng Qu, James J. Li, Gary J. Grover, Kenneth E.J. Dickinson, Neil Flynn, Dorothy Slusarchyk, Haixia Wang, David A. Gordon, Joseph A. Tino, Paul G. Sleph, Robert H. Stoffel, Ramakrishna Seethala, Leah Giupponi, Jeffrey A. Robl, Christa M. Musial, Rajasree Golla |
Rok vydání: |
2005 |
Předmět: |
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Zdroj: |
Bioorganicmedicinal chemistry letters. 15(7) |
ISSN: |
0960-894X |
Popis: |
Several novel series of tetrahydroisoquinoline 1-carboxamides were prepared and shown to be potent growth hormone (GH) secretagogues. Among them, carbamate 12a-E2 displays excellent in vivo activity by increasing plasma GH 10-fold in an anesthetized IV rat model. |
Databáze: |
OpenAIRE |
Externí odkaz: |
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