PedsQL Gastrointestinal Symptoms Scales and Gastrointestinal Worry Scales in Pediatric Patients with Inflammatory Bowel Disease in Comparison with Healthy Controls
| Autor: | James W. Varni, Chelsea Vaughan Dark, Shehzad Ahmed Saeed, Cristiane Baccin Bendo, George M. Zacur, Deborah A. Neigut, Samuel Nurko, John F. Pohl, Robert J. Shulman, Jolanda Denham, Ashish S. Patel, Miguel Saps, James P. Franciosi, Mariella M. Self |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Parents medicine.medical_specialty Adolescent Gastrointestinal Diseases Nausea media_common.quotation_subject Anxiety Severity of Illness Index Gastroenterology Inflammatory bowel disease Bloating Risk Factors Internal medicine medicine Humans Immunology and Allergy Child media_common Crohn's disease business.industry Heartburn Inflammatory Bowel Diseases Prognosis medicine.disease Ulcerative colitis digestive system diseases Diarrhea Case-Control Studies Child Preschool Quality of Life Female Worry medicine.symptom business Follow-Up Studies |
| Zdroj: | Inflammatory Bowel Diseases. 21:1115-1124 |
| ISSN: | 1078-0998 |
| DOI: | 10.1097/mib.0000000000000351 |
| Popis: | BACKGROUND Patient-reported outcomes are essential in determining the broad impact of inflammatory bowel disease (IBD) and treatments from the patient's perspective. The primary study objectives were to compare the gastrointestinal symptoms and worry of pediatric patients with IBD with matched healthy controls and to compare Crohn's disease and ulcerative colitis with each other using the Pediatric Quality of Life Inventory (PedsQL) Gastrointestinal Symptoms and Gastrointestinal Worry Scales. METHODS PedsQL Gastrointestinal Symptoms and Worry Scales were completed in a 9-site study by 256 pediatric patients with IBD and 259 parents of patients (263 families; Crohn's disease [n = 195], ulcerative colitis [n = 68]). Ten Gastrointestinal Symptoms Scales measuring stomach pain, stomach discomfort when eating, food and drink limits, trouble swallowing, heartburn and reflux, nausea and vomiting, gas and bloating, constipation, blood in poop, and diarrhea were administered along with 2 Gastrointestinal Worry Scales. A matched group of 384 healthy children families completed the PedsQL in an Internet survey. RESULTS PedsQL Gastrointestinal Symptoms and Worry Scales distinguished between pediatric patients with IBD in comparison with healthy controls (P < 0.001), with larger effect sizes for symptoms indicative of IBD, supporting known-groups validity and clinical interpretability including minimal important difference scores. Patients with Crohn's disease or ulcerative colitis did not demonstrate significantly different gastrointestinal symptoms or worry in comparison with each other. CONCLUSIONS The PedsQL Gastrointestinal Symptoms and Worry Scales may be used as common metrics across pediatric patients with IBD, including Crohn's disease and ulcerative colitis separately to measure gastrointestinal-specific symptoms in clinical research and practice. |
| Databáze: | OpenAIRE |
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