Synthesis and pharmacological validation of a novel radioligand for the orphan GPR88 receptor

Autor:	Ann M. Decker, Md Toufiqur Rahman, Chad M. Kormos, David Hesk, Emmanuel Darcq, Brigitte L. Kieffer, Chunyang Jin
Rok vydání:	2022
Předmět:	Organic Chemistry Clinical Biochemistry Drug Discovery Pharmaceutical Science Molecular Medicine Molecular Biology Biochemistry
Zdroj:	Bioorganicmedicinal chemistry letters. 80
ISSN:	1464-3405
Popis:	GPR88 is an orphan G protein-coupled receptor which has been implicated in a number of striatal-associated disorders. Herein we describe the synthesis and pharmacological characterization of the first GPR88 radioligand, [
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fbdaabe2462979b0989ea3ce391dee0 https://pubmed.ncbi.nlm.nih.gov/36587872 Zobrazit plný text záznamu Full Text from ScienceDirect