Plasma amino acids as an index for subgroups in manic depressive psychosis: Correlation to effect of tryptophan
| Autor: | K. H. Fremming, L. Kirk, S. E. Møller |
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| Rok vydání: | 1976 |
| Předmět: |
Male
Serotonin medicine.medical_specialty Bipolar Disorder Drug Resistance Manic depressive psychosis chemistry.chemical_compound Internal medicine medicine Humans Amino Acids Kynurenine Pharmacology chemistry.chemical_classification Total plasma Chemistry Tryptophan Amino acid Manic depressive Endocrinology Biochemistry Free tryptophan Female medicine.symptom Mania |
| Zdroj: | Psychopharmacology. 49:205-213 |
| ISSN: | 1432-2072 0033-3158 |
| DOI: | 10.1007/bf00427292 |
| Popis: | Two biochemical distinct groups of manic depressive patients seem to be present. One group showed a normal pattern of plasma amino acids and was resistant to oral tryptophan medication. Another group, characterized by a relative deficiency of tryptophan in plasma as measured by the ratio of total plasma tryptophan to competing amino acids, responded readily to tryptophan treatment. No significant differences could be demonstrated in the free tryptophan, total tryptophan, percentage of free tryptophan or kynurenine in the plasma between patients and controls. The findings are discussed in view of changes in the transport conditions of tryptophan from plasma into the brain. |
| Databáze: | OpenAIRE |
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